Changes in Prolactin and Insulin Resistance in PCOS Patients Undergoing Metformin Treatment: A Retrospective Study

    December 2024 in “ Journal of Clinical Medicine ”
    Tal Goldstein, Johannes Ott, Paula Katzensteiner … Marlene Hager
    Studysummary This study found that in overweight or obese women with PCOS and insulin resistance, those with lower baseline prolactin levels exhibited a greater decrease in insulin resistance after 6-8 months of metformin treatment, compared to those with higher prolactin levels.
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    Research cited in this study 7

    1. Impaired Prolactin-Lowering Effects of Metformin in Women with Polycystic Ovary Syndrome Journal of Clinical Medicine · 2023
    2. Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome Human Reproduction · 2023
    3. Pituitary Effects of Metformin in Men With Early-Onset Androgenic Alopecia The Journal of Clinical Pharmacology · 2022
    4. Male Equivalent Polycystic Ovarian Syndrome: Hormonal, Metabolic, and Clinical Aspects DOAJ (DOAJ: Directory of Open Access Journals) · 2020
    5. Comprehensive Overview of Polycystic Ovary Syndrome Nature Reviews Disease Primers · 2016
    6. Evidence-Based and Potential Benefits of Metformin in Polycystic Ovary Syndrome: A Comprehensive Review Endocrine Reviews · 2008
    7. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS) Human Reproduction · 2003