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    Glossary Nonsteroidal Inhibitors

    compounds that block biological processes without using steroids

    Nonsteroidal inhibitors are compounds that block specific biological processes without using steroid structures. In the context of hair and alopecia, these inhibitors can target enzymes or pathways involved in hair loss, such as 5-alpha-reductase, which converts testosterone to dihydrotestosterone (DHT), a hormone linked to hair thinning and loss.

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    1. Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase Journal of Medicinal Chemistry · 1993 · 89 citations
    2. Benzo[<i>c</i>]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1 Journal of Medicinal Chemistry · 2000 · 28 citations
    3. Novel Lead Generation through Hypothetical Pharmacophore Three-Dimensional Database Searching: Discovery of Isoflavonoids as Nonsteroidal Inhibitors of Rat 5α-Reductase Journal of Medicinal Chemistry · 2001 · 27 citations
    4. Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, <i>In Vitro</i>, and <i>In Silico</i> Studies ACS Omega · 2025
    5. Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, <i>InVitro</i>, and <i>In Silico</i> Studies OPAL (Open@LaTrobe) (La Trobe University) · 2025
    6. Selective non-steroidal inhibitors of 5α-reductase type 1 2004 · 49 citations
    7. Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2 Archiv Der Pharmazie · 2002 · 8 citations
    8. Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5α-reductase The Journal of Steroid Biochemistry and Molecular Biology · 2000 · 11 citations
    9. Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase Tetrahedron Letters · 1995 · 20 citations
    10. LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. Proceedings of the National Academy of Sciences of the United States of America · 1993 · 53 citations
    11. Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics Scientific Reports · 2022
    12. Novel inhibitors of 5α-reductase Expert Opinion on Therapeutic Patents · 2002 · 20 citations
    13. Sulfatase inhibitors: a patent review Expert Opinion on Therapeutic Patents · 2012 · 47 citations
    14. Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation International Journal of Nanomedicine · 2020 · 45 citations
    15. Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors Current Medicinal Chemistry · 2005 · 20 citations
    16. An overview on 5α-reductase inhibitors Steroids · 2009 · 219 citations
    17. The enzyme and inhibitors of 4-ene-3-oxosteroid 5α-oxidoreductase Steroids · 1995 · 64 citations
    18. Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition Endocrine Reviews · 2005 · 451 citations
    19. Trends in the Development of New Drugs for Treatment of Benign Prostatic Hyperplasia Current Medicinal Chemistry · 2006 · 14 citations
    20. Drug safety evaluation of exemestane Expert Opinion on Drug Safety · 2011 · 7 citations
    21. Extensive Challenges and Pending Advances in the Study of 5-Alpha-Reductase Isoenzymes. A Literature Review Latin American Journal of Development · 2024
    22. Androgen Receptor Ligands: Agonists and Antagonists Elsevier eBooks · 2017 · 2 citations
    23. Targets to treat androgen excess in polycystic ovary syndrome Expert Opinion on Therapeutic Targets · 2015 · 14 citations
    24. Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases Current Medicinal Chemistry · 2016 · 11 citations
    25. Cyclooxygenases in the skin: pharmacological and toxicological implications Toxicology and applied pharmacology · 2003 · 165 citations
    26. Three orphans one should know: red scalp, red ear and red scrotum syndrome Journal of the European Academy of Dermatology and Venereology · 2015 · 13 citations
    27. Cutaneous drug reactions Elsevier eBooks · 2010 · 1 citations
    28. Fulvestrant, a new treatment option for advanced breast cancer: tolerability versus existing agents Annals of Oncology · 2005 · 67 citations
    29. Alopecia - the search for novel agents continues Expert Opinion on Therapeutic Patents · 1997 · 11 citations
    30. Alopecia in a premenopausal breast cancer woman treated with letrozole and triptorelin Annals of Oncology · 2003 · 15 citations