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This study reports that a new DART-HRMS method can effectively analyze intact hair for drug use timelines, with cocaine detection aligning with forensic standards and identifying multiple drugs from high-resolution data.

This study provides the first crystal structure of the human SRD5A2 enzyme, revealing key insights into its function and inhibition which may aid future drug development.

This study determined the molecular structure of finasteride and its related crystalline forms, highlighting different hydrogen-bond interactions and structural configurations in various crystalline complexes.

This study reports a new one-pot method for synthesizing chromeno-pyrimidine-N-oxides with high yield from 4-chloro-3-formylcoumarin and aromatic carboximide oximes, confirmed by X-ray analysis.

This study discovered a conserved "fiber-like-motif" of melanosomes aligned in hair across various mammalian species, shedding light on the internal structure that influences hair's thermal and mechanical properties.

This review discusses molecular dynamics studies of hair keratin, highlighting newly developed computational models that replicate experimental phenomena and offering insights into molecular mechanisms.

This study found that nanostructured lipid carriers with more soybean phosphatidylcholine provided better skin retention and follicular targeting for diphencyprone compared to other formulations and controls.

This study suggests that true binary and ternary inclusion complexes were formed between finasteride and 2-hydroxypropyl-ß-cyclodextrin, with or without the addition of specific polymers.

This study identified a weak interaction between minoxidil and ß-cyclodextrin in solution, forming an inclusion complex with a 1:1 molar ratio.

This study found that Nardostachys jatamansi DC rhizome extracts and specific isolated terpenoids promoted hair growth.

This study reported that polymeric nanofibers containing minoxidil sulphate showed effective encapsulation and stability, with minimal concentration loss over six months, making them potentially ideal for delivering this unstable drug in a more visually appealing and easier-to-apply form.

Panax notoginseng may help with oral ulcers and hair growth.

This study found that oxidative treatment with peracetic acid dissociates some disulfide bonds in human hair fibers while maintaining the crystalline structure, suggesting different mechanisms stabilize different regions of intermediate filaments.

This study provided new insights into the complex and heterogeneous architecture of keratin filaments, revealing their dynamic and flexible structure through cryo-electron microscopy analysis.

Hard α-keratin in hair has a unique, nonordered structure, different from other fibers.

This study suggests that residues Val-889 and Arg-752 in the androgen receptor's steroid binding domain are crucial for NH2-/carboxyl-terminal interaction, affecting receptor stability and function.

This study reports that hair from women with breast cancer showed a unique X-ray diffraction feature, potentially offering a non-invasive method for detecting the disease.

This study found that while ethnic hair types share a common fibrous keratin structure, variations in keratin-associated proteins and lipids may lead to different macroscopic hair characteristics.

This study suggests that varying intersheet interactions may explain the differences between the two polymorphic forms of macrofibril assembly in Merino wool and hair.

This study found that micro-computed tomography (micro-CT) was highly effective for analyzing the cross-sectional geometry of hair fibres, including the medulla in highly curled hair, but less effective than scanning electron microscopy for surface details.

This study explored the solubility and crystal structure of GI197111X, a 5-alpha reductase inhibitor for androgenetic alopecia, finding its solubility in Capmul MCM suitable for a soft gel dosage form.

This study investigated the morphology and growth mechanisms of spherical crystal aggregates of minoxidil in various alcoholic solvents, finding that a n-butanol–ethyl acetate mixture produces unique spherulite aggregates with improved powder characteristics.

This study reports that structural and biochemical analysis of steroid 5α-reductases clarifies how they mediate steroid reduction with NADPH, potentially aiding in designing targeted therapies.

This study found that the molecular structure of hair is more sensitive to synchrotron X-ray radiation than its supramolecular architecture, indicating potential concerns for biological analyses using such radiation.

This study developed a simple and rapid method using silver nanoparticles to detect minoxidil concentration in hair-growth formulations, demonstrating a detection limit of 0.35 mM.

In this study, distinct metabolic profiles were identified in women with PCOS, suggesting potential biomarkers for diagnosis based on changes in lipid and androgen metabolism.

This study found that the EtOAc extract of Tridax procumbens aerial parts significantly inhibited rat paw edema and COX enzyme activity, suggesting its potential anti-inflammatory properties.