research The Human Skin as a Hormone Target and an Endocrine Gland
Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.
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research New Effects of Caffeine on Corticotropin-Releasing Hormone (CRH)-Induced Stress Along the Intrafollicular Classical Hypothalamic-Pituitary-Adrenal (HPA) Axis (CRH-R1/2, IP3-R, ACTH, MC-R2) and the Neurogenic Non-HPA Axis (Substance P, p75NTR and TrkA) in Ex Vivo Human Male Androgenetic Scalp Hair Follicles
Caffeine may help reduce stress-induced hair loss.
research Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice: A Mechanistic Systematic Review
Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.
research The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome: A Review
Changes in gut bacteria can contribute to the development of Polycystic Ovary Syndrome (PCOS), affecting metabolism, immunity, and causing inflammation. Treatments may involve adjusting these factors.
research Enzymes
Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.
research Paternal Finasteride Treatment Can Influence the Testicular Transcriptome Profile of Male Offspring—Preliminary Study
Father's finasteride use may affect son's fertility and testicular function.
research National Scientific Medical Meeting 1996 Abstracts
The document summarizes medical findings on topics like heart rhythm treatment, sleep apnea therapy, and various health conditions and treatments.
research Cystatin M/E Is a High Affinity Inhibitor of Cathepsin V and Cathepsin L by a Reactive Site Distinct from the Legumain-binding Site
Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.
research Skin Physiology in Microgravity: A 3-Month Stay Aboard ISS Induces Dermal Atrophy and Affects Cutaneous Muscle and Hair Follicles Cycling in Mice
A 3-month stay in space causes skin thinning, disrupts hair growth, and changes muscle-related genes in mice.
research Skin Transcriptome Profiling of Changthangi Goats Highlights the Relevance of Genes Involved in Pashmina Production
Changthangi goats have specific genes that help produce Pashmina wool.
research Procyanidins Attenuate Neuropathic Pain by Suppressing Matrix Metalloproteinase-9/2
Procyanidins from grape seeds reduce nerve pain by blocking specific proteins and inflammation.
research Targeting Host Cell Proteases as a Potential Treatment Strategy to Limit the Spread of SARS-CoV-2 in the Respiratory Tract
Blocking enzymes that help the virus enter cells could be a promising way to treat COVID-19.
research The Pioneer Factor SOX9 Competes for Epigenetic Factors to Switch Stem Cell Fates
SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.
research Recent Advances in Single-Cell Engineered Live Biotherapeutic Products Research for Skin Repair and Disease Treatment
Single-cell engineered biotherapeutics show promise for skin treatment but need more research and trials.
research NAC1 Directs CEP1-CEP3 Peptidase Expression and Modulates Root Hair Growth in Arabidopsis
NAC1 controls certain enzymes that reduce root hair growth in Arabidopsis.
research Genome Scan for Signatures of Adaptive Evolution in Wild African Goat (Capra Nubiana)
Wild African goats have genetic adaptations for surviving harsh desert conditions.
research Food Hypersensitivity-Induced Chronic Gastrointestinal Inflammation in a Non-Human Primate Model of Diet-Induced Obesity
A high-fat diet caused severe health problems in female macaques but was reversible with a normal diet, while male macaques reacted differently.
research Citrullinome of Porphyromonas Gingivalis Outer Membrane Vesicles: Confident Identification of Citrullinated Peptides
Citrullinated proteins from Porphyromonas gingivalis may contribute to rheumatoid arthritis.
research Hair Follicle-Targeting Drug Delivery Strategies for the Management of Hair Follicle-Associated Disorders
New hair follicle-targeting treatments show promise for hair disorders but need more research on safety and effectiveness.
research Construction of the Coexpression Network Involved in the Pathogenesis of Thyroid Eye Disease via Bioinformatics Analysis
Key genes and pathways involved in thyroid eye disease were identified, aiding potential treatment and diagnosis.
research Zinc and Zinc Transporters in Dermatology
Zinc is crucial for skin health and treating various skin disorders.
research The Genomic Variation in Textured Hair: Implications in Developing a Holistic Hair Care Routine
Afro-textured hair needs personalized care due to its unique genetic traits.
research ST14 Interacts With TMEFF1 and Is a Predictor of Poor Prognosis in Ovarian Cancer
High levels of ST14 and TMEFF1 proteins in ovarian cancer are linked to worse patient outcomes and may be a new treatment target.
research Th22 Is the Effector Cell of Thymosin β15-Induced Hair Regeneration in Mice
Th22 cells are essential for Tβ15-induced hair growth in mice.
research Developmental Mapping of Hair Follicles in the Embryonic Stages of Cashmere Goats Using Proteomic and Metabolomic Construction
Hair follicle development in cashmere goats involves dynamic changes in proteins and metabolites, with key roles for oxytocin, MAPK, and Ca2+ pathways.
research PCSK9: From Nature's Loss to Patient's Gain
Certain genetic mutations can lower bad cholesterol and reduce heart disease risk, leading to effective cholesterol-lowering drugs.
research The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed
The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.
research Irreversible And Severe Alopecia Following Docetaxel Or Paclitaxel Cytotoxic Therapy For Breast Cancer
Docetaxel and paclitaxel for breast cancer can cause permanent, severe hair loss.
research Human Hair Follicle Organ Culture: Theory, Application, and Perspectives
Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.
research Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men
Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.