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This review highlights the critical role of neuroregulation in skin wound healing, emphasizing how neurotransmitters and neuropeptides regulate inflammation, angiogenesis, and cell proliferation, and discusses potential therapeutic strategies, such as neuromodulation, to enhance these processes.

This review highlights how peripheral nerves play key roles in skin wound healing by modulating immune responses, regulating stem cell functions, and promoting vascularization, suggesting potential avenues for therapeutic strategies targeting neuroregulation.

In this study, a deep neural network model called regX was developed to prioritize driver regulators for cell state transitions by incorporating gene-level regulation and interactions, showing potential therapeutic targets in type 2 diabetes and hair follicle development when applied to single-cell multi-omics data.

This review discusses recent advancements in understanding neuroendocrine regulation of keratin biology and highlights the potential of neurohormones to treat skin disorders, but it reports no new clinical results.

This study demonstrates that neural stem cells in the adult vertebrate brain coordinate their division decisions using delayed local feedback mechanisms, involving Notch-mediated inhibition and dispersion effects, to maintain population homeostasis.

This review examines the role of nerves in regeneration across various species and discusses their importance as components in the progenitor cell niche, reporting no new clinical results.

This review discusses how neuroendocrine pathways influence keratin regulation in human skin and hair follicles and suggests these pathways as potential targets for new treatments of skin disorders, but reports no clinical results.

This study found that inhibiting neurosteroidogenesis affected GABA A receptor-mediated synaptic inhibition in immature rats but not in adults, suggesting age-dependent modulation of synaptic strength in the spinal dorsal horn.

This study found that nerve growth factor signaling in organ-cultured human hair follicles inhibits hair growth by inducing apoptosis-driven hair follicle regression.

This study found that late embryonic skin injuries can regenerate multiple tissue types, but this ability is hindered postnatally due to fibroblast-driven hyperinnervation, which can be mitigated to enable regeneration.

This study reviewed how neuropeptides and cutaneous innervation play crucial roles in the process of wound healing, suggesting they significantly influence inflammation and tissue repair phases.

This study in mice demonstrated that stress or nerve growth factor injection increases sensory neuron activity related to skin innervation, suggesting a strong connection between stress perception and neurogenic skin inflammation.

This review discusses neural mechanisms involved in hair growth control, focusing on piloneural interactions, but reports no clinical findings; the authors suggest further exploration for managing hair growth disorders.

This review discusses molecular regulatory circuitry in organ regeneration, using skin regeneration examples, and reports no new experimental results; the authors propose that understanding this circuitry might aid in developing therapeutic strategies.

This review discusses the roles of prostaglandins in the nervous system and their therapeutic potential for neurological diseases, noting their complex interactions with immune cells and signaling pathways.

This systematic review found that interventions targeting neuropeptides and neurotransmitters, particularly melatonin, substance P, and oxytocin, show consistent evidence for anti-inflammatory, reparative, and psychodermatologic benefits, highlighting the potential of neurohormonal signaling as a therapeutic target in dermatology.

This review discusses how various nutrients, such as flavonoids, probiotics, and omega-3 fatty acids, may support brain health by targeting stress-related pathways, potentially offering protective effects against neurodegenerative and psychiatric disorders through their roles in oxidative stress reduction and neuroinflammation regulation.

In this theoretical study, axolotl spinal cord regeneration was modeled using a reaction-diffusion process, suggesting that the control of regenerative response relies on cell sensitivity to the signal and its diffusion characteristics, laying groundwork for identifying the signaling mechanism.

In this theoretical study, the authors developed a computational model to explore whether a reaction-diffusion process could explain the signal inducing axolotl spinal cord regeneration, proposing that regeneration control depends on cell sensitivity to the signal and its diffusion characteristics.

This review discusses the role of oestrogens in stimulating growth hormone secretion and influencing linear bone growth in children, and reports no new clinical results; the authors suggest that oestrogens play a key role in pubertal growth spurts for both genders.

This article reviews the therapeutic potential of potassium channel openers for various conditions related to metabolic distress but does not report new clinical results; it emphasizes the need for further research.

This review discusses the therapeutic potential of potassium channel openers for various conditions, but notes that their clinical role is not yet fully established.

This review discusses the role of oestrogens in stimulating linear bone growth and pubertal changes in both boys and girls, highlighting their influence on the growth hormone-insulin-like growth factor axis; it reports no new clinical results.

This review of TMJ disorders discusses the promising potential of using a combination of platelet-rich plasma and hyaluronic acid in TMJ arthrocentesis, noting significant pain reduction and improved mobility, but calls for more extensive trials to confirm long-term efficacy and safety.

This study suggests that while complementary and alternative treatments for hair loss are becoming more popular, their effectiveness and mechanisms remain largely unverified.

This study found that a mesenchymal stromal cell-derived regenerative extracellular matrix (rECM) significantly accelerated wound closure and improved healing in diabetic mice, also enhancing nerve and blood vessel formation compared to controls.

This study explores the potential of platelet-rich plasma (PRP) as a novel adjuvant therapy for eczema, positing that it may alleviate inflammation, enhance skin barrier function, and reduce recurrence.

This study found that neurosteroids can reorganize GABA A receptors in mice, mimicking ovarian cycle changes, with the process being mediated by neurosteroid levels rather than direct hormone receptor activation.

EGFR is essential for organized skin nerve growth and branching.

In this study, the authors review how epigenetic regulation influences the role of iPSC-derived neural stem/progenitor cells in spinal cord injury therapy, highlighting challenges in the cells' generation, differentiation, and transplantation, and the effect of therapeutic tools on these processes.