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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Manipulating the catagen and telogen phases of hair growth could lead to treatments for hair disorders.

Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.

Medications have become the main treatment for enlarged prostate symptoms, replacing surgery and watchful waiting.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.

Four-amino acid part makes enzyme sensitive to finasteride.

Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.

Blocking the virus's entry into cells by targeting certain pathways could lead to early COVID-19 treatments.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

Androgens play a role in female sexual function, and testosterone therapy can help women with low sexual desire, but more research is needed on treatments and long-term safety.

Hair grays due to oxidative stress and fewer functioning melanocytes.

Stress can worsen skin conditions by affecting hormone levels and immune response.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Neurosteroids show promise for treating epilepsy and more research is needed.

Male pattern hair loss caused by follicular miniaturization; early diagnosis and treatment can reduce psychological burden.

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Red Ginseng Extract may help human hair grow by activating growth pathways and blocking negative effects of certain hormones.

Androgens may block hair growth signals, targeting this could treat hair loss.

A transwoman developed a brain tumor after nine years of hormone therapy, suggesting a possible link between the treatment and tumor development.

17-β-Estradiol applied to the skin stops hair growth, while ICI 182 780 helps hair grow in mice.

Late pregnancy helps repair brain damage in rats due to the GABAergic system.

The conclusion is that future hair loss treatments should target the root causes of hair thinning, not just promote hair growth.

Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.

Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.