26 citations
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September 2009 in “Psychosomatics” This case report highlights the importance of recognizing that neuropsychiatric symptoms in adolescents may signal the onset of systemic lupus erythematosus rather than a primary psychiatric disorder.
20 citations
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October 2018 in “Clinical Drug Investigation” This study observed that men receiving dutasteride for benign prostatic hyperplasia did not show significant differences in neuropsychological assessments compared to a control group not on dutasteride.
1 citations
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May 2022 in “Frontiers in Psychiatry” In this case study, a 33-year-old female with neuropsychiatric systemic lupus erythematosus experienced hair regrowth with no further loss after receiving a combination of systemic and local treatments.
Dr. Mayer Brezis argues that a study by Wang et al. incorrectly concluded that finasteride does not cause depression or suicide, due to methodological flaws, and suggests halting its marketing under the precautionary principle.
In this letter, Dr. Mayer Brezis critiques a study on finasteride's mental health impact, arguing that its dismissal of links between the drug and depression or suicide is flawed; he suggests market withdrawal due to established neuropsychiatric risks.
February 2026 in “NeuroSci” This systematic review synthesizes evidence on the distribution of 5a-reductase isozymes and their implications for mental health, finding that inhibition of neurosteroidogenesis may contribute to anxiety, depression, and suicidality, with some patients experiencing persistent psychiatric effects from finasteride or dutasteride.
December 2025 in “The Journal of Clinical Psychiatry” Finasteride can cause depression and suicidal thoughts; safer alternatives are recommended.
November 2025 in “Stem Cell Reviews and Reports” The error in figures didn't affect the study's results or conclusions.
In this case report, a patient's atypical neuropsychiatric and dermatological symptoms were crucial for diagnosing systemic lupus erythematosus, highlighting the disease's clinical heterogeneity and the importance of early detection to prevent organ damage.
In this case report, a 19-year-old woman with systemic lupus erythematosus experienced significant improvement in neuropsychiatric symptoms, including psychosis and seizures, following treatment with high-dose corticosteroids, immunosuppressants, and antidepressants.
April 2018 in “African journal of rheumatology” This case report describes a teenager with Systemic Lupus Erythematosus experiencing neuropsychiatric symptoms, highlighting diagnostic criteria and laboratory findings, but reports no new treatment outcomes.
This study presents a case of neuropsychiatric lupus in a 50-year-old woman, highlighting the severe impact on quality of life and the necessity for aggressive treatment to improve outcomes.
1 citations
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July 2020 in “Acta Neuropsychologica” This study observed that valproic acid treatment led to a significant reduction in aggressive and impulsive behaviors among patients with acquired brain injury, with varying effects based on cognitive impairment degree; the treatment was generally well-tolerated, though some patients experienced temporary side effects.
November 2024 in “Rheumatology Advances in Practice” A thorough, team-based approach and clear communication improve outcomes in complex neuropsychiatric lupus cases.
December 2021 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found a significant association between montelukast and neuropsychiatric adverse events such as suicidal ideation and depression, suggesting that the drug's interaction with specific genes may contribute to these effects.
August 2008 in “European Neuropsychopharmacology” This study identified significant correlations between self-esteem, psychiatric symptoms, and health-related quality of life in peritoneal dialysis patients.
February 2026 in “Journal of Dermatology and Skin Science” This review suggests a causal relationship between finasteride, used for hair loss, and persistent neuropsychiatric side effects like depression, citing evidence that fulfills key causality criteria and calls for cautious use along with strengthened regulatory oversight.
July 2025 in “Reactions Weekly”
10 citations
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May 2018 in “Neuropharmacology” This study suggests that inhibitors of steroidogenic enzymes may have therapeutic potential for certain behavioral disorders linked to dopaminergic hyperfunction, despite concerns about their endocrine impacts.
December 2025 in “The Journal of Clinical Psychiatry” Finasteride is not proven to cause depression or suicide, and careful patient monitoring is advised.
1 citations
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May 2025 in “The Journal of Rheumatology” This case report highlights the challenge of distinguishing between neuropsychiatric lupus and rituximab-associated progressive multifocal leukoencephalopathy in systemic lupus erythematosus patients, emphasizing the importance of early recognition and careful management.
72 citations
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January 2011 in “Current Pharmaceutical Design” This review discusses the potential role of steroid 5α-reductase inhibitors in treating neuropsychiatric disorders related to dopaminergic hyperreactivity but reports no new clinical results.
In this study, young adult male albino rats treated with finasteride showed a 10% reduction in thickness of the CA1 layer of the hippocampus, suggesting that this atrophy may contribute to memory impairments linked to Post-Finasteride Syndrome.
October 2023 in “IBRO neuroscience reports” Rat hair follicle stem cells have functional oxytocin receptors, useful for studying neuropsychiatric disorders.
August 2023 in “Stem cell reviews and reports” July 2008 in “Planta Medica” This study found that Acanthus montanus leaves' aqueous extract is a developmental toxicant in rats, leading to several adverse effects on offspring when used during pregnancy.
54 citations
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February 2012 in “Pediatrics in Review” This article discusses systemic lupus erythematosus, covering its clinical features, treatments, and the recent FDA approval of belimumab, but does not present new clinical results.
49 citations
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February 2009 in “Clinical Rheumatology” This study observed that systemic lupus erythematosus may not be as uncommon among African Blacks as previously reported, highlighting the need for early aggressive treatment.
5 citations
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November 1992 in “Current problems in dermatology” This review discusses the role of glucocorticoids in treating severe inflammatory disorders and highlights their potential adverse effects, recommending dosage management to minimize these risks; no new clinical results are reported.
2 citations
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March 2026 in “Journal of Dermatological Treatment” This study found that JAK inhibitors used to treat alopecia areata have varied safety profiles, with different adverse events associated with each drug; tofacitinib and ruxolitinib had earlier onset of events, while baricitinib and ritlecitinib showed distinct delayed patterns.