Neuropsychiatric Lupus: A Severe Manifestation of Systemic Lupus Erythematosus

March 2018

Panagiotis Athanassiou, Charoula Katsavouni, Marina Gatsiou, Aikaterini Tzanavari, Charalampos Gerodimos

systemic lupus erythematosus neuropsychiatric lupus epileptic convulsions dysarthria delusions EEG SPECT methylprednisolone cyclophosphamide muscle weakness arthritis SLE MRI pulse steroids

TLDR Neuropsychiatric lupus is a severe form of lupus that needs strong treatment to improve life quality.

The study described a 50-year-old female patient with a 20-year history of systemic lupus erythematosus (SLE) who developed severe neuropsychiatric manifestations, including epileptic convulsions, dysarthria, and delusions. Despite normal brain MRI results, EEG and SPECT scans showed abnormalities. Treatment with pulse methylprednisolone and cyclophosphamide led to disease remission, although the patient experienced muscle weakness and arthritis during stabilization. The study concluded that neuropsychiatric lupus is a severe and complex manifestation of SLE that significantly impacts quality of life and requires aggressive treatment to improve outcomes.

View this study on lupus.bmj.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 992 results

community Hair Remedies that Don't Work for Anybody Seeking Hair Regrowth

in Treatment 7 upvotes 4 years ago

Hair loss treatments discussed include minoxidil, finasteride, and RU58841. Salon products and supplements generally don't work for hair regrowth unless there's a severe nutritional deficiency, while hormonal treatments like estrogen and spironolactone can be effective.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community 2024 guide for male pattern baldness: 10 take home messages from Dr. Moreno-Arrones

in Research/Science 243 upvotes 1 month ago

Effective treatments for male pattern baldness include finasteride, dutasteride, and oral minoxidil. Non-effective approaches include oils, shampoos, serums, laser therapies, massages, vitamins, and microneedling.

community Minoxidil Finasteride heart problems

in Update 97 upvotes 6 months ago

A user experienced heart problems after taking 1mg finasteride and 2.5mg oral minoxidil and is considering quitting minoxidil. Others discussed their experiences with heart issues and minoxidil, with some suggesting topical minoxidil as a safer alternative.

community Seeking Advice: Unusual Hair Loss at 31 Years Old - Any Insights? (M)

in Chat 15 upvotes 7 months ago

A 31-year-old man who previously had good results with minoxidil, finasteride, and nizoral for hair loss is now experiencing unusual hair loss and side effects from finasteride. Respondents suggest it might be severe retrograde alopecia and recommend exploring other treatment options due to his inability to tolerate finasteride.

community A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

in Research/Science 6 upvotes 5 months ago

Topical formulations, natural products, and CAM therapies are being used to treat Androgenic alopecia to avoid side effects of Finasteride and Minoxidil. The review covers various low-risk, alternative treatment options.

Similar Research

5 / 1000+ results

research Proceedings of the RAMI Intern Section Meeting, 18th January 2014

2 citations, July 2014 in “Irish Journal of Medical Science”

The meeting discussed medical findings, including benefits of certain treatments for cancer and heart conditions, and highlighted issues like poor adherence to preventive measures and skill gaps among interns.

Comprehensive Evaluation of Neuropsychiatric and Mucocutaneous Manifestations in the Diagnosis of Systemic Lupus Erythematosus: A Complete Clinical Approach to a Case

research Comprehensive Evaluation of Neuropsychiatric and Mucocutaneous Manifestations in the Diagnosis of Systemic Lupus Erythematosus: A Complete Clinical Approach to a Case

October 2023 in “Curēus”

Recognizing unusual brain and skin symptoms is crucial for diagnosing lupus early.

A Case of Neuropsychiatric Systemic Lupus Erythematosus With Hair Loss as the First Diagnostic Symptom