Finasteride-Induced Neuropsychiatric Reactions
February 2026
in “
Journal of Dermatology and Skin Science
”
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Studysummary This review suggests a causal relationship between finasteride, used for hair loss, and persistent neuropsychiatric side effects like depression, citing evidence that fulfills key causality criteria and calls for cautious use along with strengthened regulatory oversight.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Finasteride, commonly used for androgenetic alopecia, has been linked to persistent neuropsychiatric adverse effects such as depression, anxiety, cognitive impairment, and suicidality. Evidence from various studies supports a causal relationship, highlighting issues like reduced neurosteroid synthesis affecting mood and neurogenesis. Regulatory bodies have updated safety warnings, and some countries now require informed consent before prescription. Despite its short-term efficacy for hair loss, the long-term benefits are unclear, and there's a significant increase in depression risk. Given alopecia's cosmetic nature and alternative treatments, the precautionary principle suggests avoiding finasteride, emphasizing the need for comprehensive risk disclosure and shared decision-making in clinical practice.
