Developmental and Reproductive Outcome of F1 Generation of Wistar Rats Exposed to Acanthus Montanus Aqueous Extract During Organogenesis

    July 2008 in “ Planta Medica ”
    EA Asongalem, P Nana, HS Foyet, T Dimo, P. Kamtchouing
    TLDR Acanthus montanus extract harms fetal development and causes infertility in offspring.
    The study investigated the effects of Acanthus montanus aqueous extract (AMAE) on pregnant Wistar rats and their offspring. Pregnant rats were given varying doses of AMAE during organogenesis, and the offspring were monitored for developmental and reproductive outcomes. The study found that while maternal rats showed no weight loss or toxicity, the offspring experienced several adverse effects, including decreased fetal body weights, delayed developmental milestones, limb deformations, inflamed eyes, hair loss, and impaired behavioral functions. Additionally, all exposed offspring were infertile. The study concluded that AMAE acted as a developmental toxicant, and its use during the first trimester of pregnancy should be avoided.
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