January 2025 in “Cosmetics” In this study, a systematic review highlighted the potential of exosomes in cosmetics and regenerative medicine for improving skin rejuvenation and addressing aging, while also pointing out existing challenges such as regulatory hurdles and the need for more clinical validation.
October 2014 in “Microscopy” This study found that using ionic liquid for specimen preparation allowed for observation of dermal papilla cells and their cilia in near-living conditions, reducing damage typically caused by conventional preparation methods.
7 citations
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October 2023 in “European Journal of Pharmacology” This study found that Cannabidivarin (CBDV) promotes neuronal differentiation and inhibits oligodendrocyte maturation via TRPV1 modulation, highlighting its potential in neural stem cell research.
1 citations
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July 2024 in “Journal of Investigative Dermatology” Immune cells boost stem cell activity in hairy moles, causing more hair growth.
January 2020 in “Hair transplant forum international” This review discusses exosomal micro RNAs from dermal papilla cells in hair follicle mediation and reports no new clinical results.
April 2021 in “Journal of Investigative Dermatology” This study found that multicomponent microarray patches for SARS-CoV-2 vaccination produced stronger immune responses and fewer side effects in mice compared to traditional intramuscular injection.
August 2024 in “International Journal of Dermatology” This research commentary discusses the potential role of exosomes in treating hair loss, although no results are reported. The authors highlight prior studies indicating exosomes' promise for hair regeneration and explore their emerging application in dermatology.
2 citations
,
February 2025 in “Advanced Healthcare Materials” This study developed microfluidics-based 3D microtumors to model minimal residual disease in ovarian cancer, highlighting their alignment with patient-derived MRD and response to a fatty acid oxidation inhibitor.
This study found that a bioorthogonal microneedle patch delivering AAV-aFGF effectively improved hair follicle regeneration and sustained hair growth in murine alopecia models compared to other methods.
54 citations
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June 2020 in “Pharmaceutics” This review discusses the advancements in using "soft" colloidal nanocarriers for delivering photosensitive agents and highlights their potential applications in treating diseases like cancer, but it reports no new clinical results.
17 citations
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September 2014 in “PLoS ONE” This study found that SK2 channels in sensory terminals of rat muscle spindles and hair follicles may play a crucial role in modulating mechanosensory transduction by influencing receptor potentials through Ca2+-activated K+ currents.
July 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” This study developed a potent Wnt surrogate with high specificity for the Fzd7 receptor in mice, promoting full hair follicle regeneration and robust hair growth, suggesting potential applications in tissue development and targeted regeneration.
15 citations
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January 1992 in “Sen'i Gakkaishi” This study suggests that the cell membrane complex in hair cuticles contains hydrophilic regions with disulfide bonds allowing polymer uptake and hydrophobic lamella-like lipid layers.
2 citations
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September 2022 in “Drug Delivery” This study found that a transdermal drug delivery system using nanostructured lipid carriers and polymeric microneedles for β-sitosterol significantly enhanced hair growth in testosterone-induced alopecia rats, suggesting potential for treating androgenic alopecia.
1 citations
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September 2025 in “Scientific Reports” This study reported that a colistin sulfate-loaded nanoemulgel showed improved antimicrobial activity and skin permeability compared to a CS solution, suggesting a potential new approach for treating severe infections caused by multidrug-resistant bacteria.
September 2026 in “medRxiv” This study found that the combination of recombinant growth factors and plant-derived extracellular vesicles significantly improved scalp regulation, hair growth, thickness, and density, and reduced hair shedding in the tested formulation by Day 56.
26 citations
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April 2024 in “Particle and Fibre Toxicology” In this study, researchers investigated the penetration and cellular responses to nanoplastics in human skin models with compromised barriers, finding that nanoplastics can penetrate the skin, accumulate in cells, and trigger inflammatory responses through specific signaling pathways.
41 citations
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July 2016 in “Journal of Investigative Dermatology” This study identified molecular differences between dysplastic nevi and common melanocytic nevi, including altered keratinocyte differentiation, increased hair follicle-related molecule expression, and distinct immune microenvironment characteristics in dysplastic nevi.
January 2025 in “Regenerative Biomaterials” This study investigated a new treatment for androgenetic alopecia using curcumin-primed milk-derived extracellular vesicles in a mouse model, finding that these vesicles improved hair follicle health and promoted hair regeneration by modulating key signaling pathways and reducing inflammation.
April 2026 in “Journal of Nanobiotechnology” In this study, researchers developed a leech-inspired microneedle platform for targeted delivery of metformin to hair follicle cells, which showed promising results in reducing inflammation and oxidative stress and promoting hair growth, offering a potential new treatment strategy for androgenetic alopecia.
July 2026 in “Pharmaceuticals” This review discusses the potential of marine-derived polysaccharide nanofibers as advanced wound dressings, highlighting their regenerative advantages in addressing inflammation, oxidative stress, and other healing barriers. However, it notes that clinical translation is limited by challenges in standardization, evidence, safety, and production scalability.
December 2023 in “Melatonin research” This review highlights the potential of using melatonin-loaded nanocarriers to enhance drug delivery efficiency and reduce side effects, emphasizing their promise in treating various diseases through targeted and precise delivery methods.
7 citations
,
August 2023 in “Frontiers in Cardiovascular Medicine” This review discusses recent preclinical strategies for enhancing mesenchymal stem cell delivery to ischemic cardiac and peripheral tissues but reports no clinical results.
9 citations
,
March 2017 in “Journal of Visualized Experiments” This study introduced a novel in vitro murine assay using transgenic mice to identify immunomodulatory compounds, which identified 160 potential hits from 4,398 compounds screened.
39 citations
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August 2017 in “Colloids and Surfaces B: Biointerfaces” This study found that 50-nm PLGA nanoparticles delivered with iontophoresis enhanced skin permeation of indomethacin in rats more effectively than 100-nm nanoparticles, suggesting improved targeting of hair follicles.
12 citations
,
September 2020 in “Nanomaterials” This study found that centrifugally spun scaffolds with higher concentrations of platelet-derived bioactive molecules enhanced melanocyte metabolic activity and proliferation, suggesting potential for improving vitiligo treatment.
61 citations
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March 1966 in “Archives of Dermatology” This study found that nevoid basal cell carcinomas originate in the epidermis and upper hair follicles, resembling early nonnevoid basal cell carcinoma proliferations.
21 citations
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November 2020 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that low massage frequencies like 4.2 Hz enhance nanoparticle penetration into hair follicles more effectively than higher frequencies, indicating potential applications in therapeutic and cosmetic delivery.
40 citations
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April 1999 in “Journal of Histochemistry & Cytochemistry” In this study, the researchers identified the specific subcellular localization of the protein S100A3 in the endocuticle and cortex of human hair shafts.