A Study of the Expression of Small Conductance Calcium-Activated Potassium Channels (SK1-3) in Sensory Endings of Muscle Spindles and Lanceolate Endings of Hair Follicles in the Rat

    September 2014 in “ PLoS ONE ”
    Fiona C. Shenton, Guy S. Bewick, Robert W. Banks
    TLDR SK2 channels help control sensory signals in rat muscle spindles and hair follicles.
    The study investigated the expression of small conductance Ca2+-activated K+ channels (SK1-3) in sensory endings of muscle spindles and lanceolate endings of hair follicles in rats. Using immunocytochemistry, it was found that SK1 was not present in sensory terminals of either structure, while SK2 was detected in both muscle spindles and lanceolate endings, colocalizing with synaptic-like vesicle and glial cell markers. SK3 was absent in muscle spindles but present in hair follicle endings, mainly in satellite glial cells. The differential distribution of SK channels suggested their role in modulating mechanosensory transduction by regulating sensory terminal excitability, with SK2 playing a significant role in receptor potential formation in both mechanoreceptor types.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community P-1075: a BETTER version of Minoxidil

      in Research/Science 1 month ago
      P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

      community Small hairs emerging over the past month.

      in Progress Pictures  40 upvotes 7 months ago
      A user reported using oral Minoxidil 3mg, oral Finasteride 1mg, topical Minoxidil, dermarolling twice a week, and taking biotin and vitamin D daily for 10 weeks. They noticed small hairs growing at the hairline after 6 weeks.

      community Small progress after 1 year 35m

      in Progress Pictures  184 upvotes 1 year ago
      A man saw improvement in hair loss after a year using 1mg finasteride daily and minoxidil twice daily, but reduced finasteride due to side effects. He switched to 0.5mg dutasteride daily, topical finasteride twice daily, microneedling weekly, and 2.5mg oral minoxidil, but may stop minoxidil due to chest pains.

      community Small study on zinc and arginine

      in Research/Science  16 upvotes 4 years ago
      The conversation discusses hair loss treatments, specifically mentioning Minoxidil, finasteride, and RU58841. It also touches on a study involving zinc and L-arginine.

    Similar Research

    5 / 1000+ results