A Study of the Expression of Small Conductance Calcium-Activated Potassium Channels (SK1-3) in Sensory Endings of Muscle Spindles and Lanceolate Endings of Hair Follicles in the Rat

    September 2014 in “ PLoS ONE ”
    Fiona C. Shenton, Guy S. Bewick, Robert W. Banks
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    TLDR SK2 channels help control sensory signals in rat muscle spindles and hair follicles.
    The study investigated the expression of small conductance Ca2+-activated K+ channels (SK1-3) in sensory endings of muscle spindles and lanceolate endings of hair follicles in rats. Using immunocytochemistry, it was found that SK1 was not present in sensory terminals of either structure, while SK2 was detected in both muscle spindles and lanceolate endings, colocalizing with synaptic-like vesicle and glial cell markers. SK3 was absent in muscle spindles but present in hair follicle endings, mainly in satellite glial cells. The differential distribution of SK channels suggested their role in modulating mechanosensory transduction by regulating sensory terminal excitability, with SK2 playing a significant role in receptor potential formation in both mechanoreceptor types.
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