August 2023 in “Research Square (Research Square)” In this study, researchers observed that Melan A, a melanocytic marker, was significantly expressed in hair follicles of alopecia areata patients and correlated with immune infiltrates, suggesting melanocytes might contribute to the autoimmune response in this condition.
August 2023 in “International Journal of Molecular Sciences” This study observed unexpected heterogeneity among pigment cells in human scalp hair follicles, identifying immature melanocyte populations outside traditional pigment production zones, raising questions about their potential roles beyond melanin synthesis.
In this study, researchers explored the heterogeneity of pigment cells in the human scalp anagen hair follicle bulb and discovered unexpected subpopulations of melanocytes, including immature SOX10-negative cells, highlighting potential non-melanogenic roles or transitional migratory functions that require further investigation.
This article reviews the variations and risks associated with skin conditions in melanin-rich individuals, including assessment challenges and complications from common skin treatments, but presents no new research findings.
January 2019 in “DSpace@MIT (Massachusetts Institute of Technology)” This study found that increased PHGDH expression in mice led to earlier melanin and melanocyte presence in hair follicles but did not induce cancer.
This study found that Polygonum multiflorum radix ethanol extract may promote melanin synthesis, potentially helping to turn gray hair back to black by enhancing antioxidant activity and increasing tyrosinase expression.
January 2017 in “Archives of clinical and biomedical research” This case report suggests that melanin, as an energy generator, may offer a new perspective on studying and treating autoimmune disorders such as alopecia areata.
35 citations
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January 1981
19 citations
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November 2023 in “npj Regenerative Medicine” This study found that synthetic melanin particles applied topically in mouse injury models improved wound healing, showing potential as a therapy for accelerated healing, including in human skin explants.
13 citations
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April 2022 in “Frontiers in oncology” This review discusses the early phases of melanomagenesis and the factors influencing melanoma cell variability and reports no new clinical results.
In this study, researchers developed a novel bio-patch from decellularized freeze-dried tumor tissues and hair melanin nanoparticles, which demonstrated enhanced wound healing in vivo by reducing oxidative stress, suppressing inflammation, and promoting angiogenesis.
July 2024 in “Journal of Cosmetic Dermatology” This study on rats found that topical application of bacterial melanin significantly stimulates hair growth by prolonging the anagen phase and enhancing vasodilation in the treated skin areas compared to controls, suggesting its potential as a cost-effective hair growth treatment.
January 2016 in “UNESP Institutional Repository (São Paulo State University)” This study suggests that the phenotype of melasma in women is influenced by structural and cellular changes across the epidermal-melanin unit, not just melanocyte hypertrophy, highlighting potential roles for dermal damage repair and fibroblast senescence.
October 2025 in “Molecular Genetics and Genomics” July 2024 in “Journal of Investigative Dermatology” This study found that four bacterial isolates from a microbiology laboratory collection demonstrated resistance to selenate, with molecular analysis showing they closely resemble different strains of Bacillus megaterium.
50 citations
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February 2004 in “Journal of Investigative Dermatology” 10 citations
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August 2023 in “Animals” In this study, researchers examined chicken feather follicle tissues from differently colored chickens and found that the genes SLC45A2 and GPNMB are involved in promoting melanin deposition, which enriches understanding of the genetic mechanisms affecting feather color.
This community service event in Malang, Indonesia, reported positive responses to using virgin coconut oil and fish oil as supportive therapy for treating fungal infections in cats, promoting hair regeneration, and educating pet owners.
April 2024 in “JOURNAL OF Mental Health Concerns” This study observed that self-affirmation therapy significantly reduced anxiety levels in students before they carried out structured presentation tasks, as indicated by statistical analysis showing a p-value of 0.000.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that early pigment cell markers Sox10 and c-KIT, as well as DCT/TRP-2, were detectable in melanogenically-active melanocytes of the anagen bulb in human hair follicles.
June 2022 in “Journal of Experimental Biology and Agricultural Sciences” In this study, researchers identified high levels of multidrug resistance in E. coli samples from broiler chickens in Malang Regency, with all positive samples resistant to multiple antibiotics including Erythromycin, Bacitracin, and Amoxicillin.
2 citations
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November 1998 in “Journal of The European Academy of Dermatology and Venereology” This study focused on the ultrastructural and immunohistochemical aspects of dermal mast cells in systemic mastocytosis and their interaction with the epidermal melanin unit.
This study observed a significant correlation between stress levels and hair loss (telogen effluvium) among first-year female medical students at Muhammadiyah Malang University.
489 citations
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June 2005 in “The FASEB Journal” This study found that human scalp hair follicles can respond to corticotropin releasing hormone stimulation similarly to the classical HPA axis, including up-regulating cortisol production and activating neuroendocrine feedback loops.
450 citations
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January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This article reviews follicular melanogenesis, detailing how melanin synthesis and its regulation in hair follicles depend on a complex interplay of cellular and molecular mechanisms, but reports no new clinical findings.
303 citations
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August 1971 in “The American Journal of Medicine” This report suggests that in vitiligo, melanocytes may be destroyed by the same factors necessary for melanin production, contributing to the skin's depigmentation.
240 citations
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April 2011 in “Pigment Cell & Melanoma Research” This review discusses the identification and characteristics of melanocyte stem cells, emphasizing their role in hair pigmentation, greying, and skin repigmentation, but reports no new research findings.