42 citations,
December 2016 in “Cell Death & Differentiation” Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.
35 citations,
May 2021 in “Nature communications” The skin's basement membrane has specialized structures and molecules for different tissue interactions, important for hair growth and attachment.
35 citations,
November 2017 in “Trends in Molecular Medicine” Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.
29 citations,
December 2005 in “BioEssays” Wnt/ß-catenin signaling is crucial for regulating skin stem cells and hair growth, with the right levels and timing needed for proper function.
28 citations,
August 2018 in “BMC genomics” DNA methylation changes are linked to hair growth cycles in goats.
27 citations,
March 2014 in “Endocrinology” Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.
16 citations,
July 2020 in “Advanced functional materials” 3D cell-derived matrices improve tissue regeneration and disease modeling.
15 citations,
October 2014 in “Journal of Investigative Dermatology” New treatments targeting the Hedgehog pathway can help treat advanced skin cancer but may have side effects and their effectiveness in early stages is unknown.
14 citations,
April 2021 in “Journal of Investigative Dermatology” Aging causes changes in the scalp that can affect hair growth and lead to older-looking hair in women.
14 citations,
November 1982 in “British Journal of Dermatology” Testosterone conversion to 5α-DHT may not be essential for its effects on the skin.
11 citations,
August 2017 in “Journal of The European Academy of Dermatology and Venereology” Found different long non-coding RNAs in balding Chinese men, which may help create new treatments.
11 citations,
July 2016 in “Endocrinology” Higher Lnk protein levels in ovaries may lead to insulin resistance in women with PCOS.
10 citations,
May 2019 in “Toxicological Sciences” Finasteride exposure affects gene expression and anogenital distance in male rat fetuses.
10 citations,
July 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” FP-1 is a key protein in rat hair growth, active only during the growth phase.
9 citations,
May 2012 in “Journal of Craniofacial Surgery” Submental tissue is good for repairing mouth area skin with minimal scarring and good cosmetic results.
8 citations,
July 2014 in “General and Comparative Endocrinology” Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.
8 citations,
October 2008 in “Medical hypotheses” Baldness might be caused by scalp weight pressing on hair follicles.
4 citations,
April 2021 in “Experimental and Molecular Medicine” The conclusion is that certain genetic factors and blood types may affect COVID-19 severity, but changes in ACE2 and TMPRSS2 genes are not clearly linked to it.
4 citations,
October 1988 in “Clinics in Dermatology” Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.
3 citations,
July 2014 in “Indian Journal of Surgery” Sex hormones might influence bladder cancer development, and aromatase inhibitors could increase risk in postmenopausal women.
2 citations,
August 2020 in “Scientific reports” Genes related to keratin, skin cell differentiation, and immune functions are key in hedgehog skin and spine development.
2 citations,
January 2018 in “Recent clinical techniques, results, and research in wounds” Low-Level Laser Therapy helps heal wounds and regenerate tissue when used correctly.
2 citations,
November 2012 in “InTech eBooks” The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.
2 citations,
January 1994 in “Yakubutsu dōtai” Finasteride has different absorption and metabolism in male and female rats, with higher concentrations in certain organs and mostly excreted through feces.
1 citations,
April 2021 in “Current Stem Cell Reports” Eating less can improve stem cell function and increase lifespan.
1 citations,
January 2013 in “MedChemComm” PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.
1 citations,
February 2004 in “Dermatologic Surgery” Deep Plane Fixation in scalp surgeries allows for more tissue removal with less tension, leading to better healing and less scarring.
December 2023 in “Journal of the Endocrine Society” Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.
September 2023 in “Medical records-international medical journal” Decreased IGF-1R expression may contribute to sacrococcygeal pilonidal sinus development.
July 2022 in “Research Square (Research Square)” Certain miRNAs may play a role in sheep hair follicle development, which could help improve wool production.