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research Digital measurement of melasma: Towards eliminating subjectivity from treatment evaluation
The digital system for measuring melasma shows promise but needs more development for better accuracy and automation.
research May AMH levels distinguish LOCAH from PCOS among hirsute women?
This study concluded that antimullerian hormone levels are not generally effective for distinguishing late onset congenital adrenal hyperplasia from all hyperandrogenic polycystic ovary syndrome subtypes, except one specific subtype.
research A gene for monilethrix is closely linked to the type II keratin gene cluster at 12q13
This study mapped monilethrix, a hereditary hair and nail disorder, to the type II keratin cluster on chromosome 12q, marking the first primary human hair disorder localization and implicating defects in "hard" keratins.
research Faculty Opinions recommendation of Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia.
This review discusses the effects of mineralocorticoid receptor overexpression in mice skin, reporting no new data but highlighting its link to epidermal atrophy, early barrier formation, eye issues, and hair loss.
research A practical guide on Polyendocrine Metabolic Ovarian Syndrome (PMOS) for Clinicians
This review discusses the proposed shift from PCOS to PMOS, emphasizing a comprehensive approach to diagnosis and management, but reports no new clinical results.
research Epidermal and Hair Follicle Progenitor Cells Express Melanoma-Associated Chondroitin Sulfate Proteoglycan Core Protein
MCSP may help identify and regulate skin stem cells, affecting hair growth and regeneration.
research A molecular systems architecture of the mesenchymal stromal cell microenvironment
This study developed a molecular systems architecture to map the complex interactions between mesenchymal stromal cells and their microenvironment, providing a framework for future predictive models that could enhance therapeutic strategies and reduce adverse effects.
research Genomic and functional characterization of a novel halophilic bacteriophage targeting carbapenem-resistant Klebsiella pneumoniae
This study found that the novel bacteriophage Halo KS-7 shows strong antibacterial activity against carbapenem-resistant Klebsiella pneumoniae and significantly promotes wound healing in mice, making it a promising biocontrol agent for managing multidrug-resistant infections.
research Effects of Microwave-Assisted Opuntia humifusa Extract in Inhibiting the Impacts of Particulate Matter on Human Keratinocyte Skin Cell
This study found that microwave-assisted Opuntia humifusa extract improved antioxidant and anti-inflammatory properties to counteract particulate matter's harmful effects on HaCaT keratinocytes.
research MHC Class I-Like MILL Molecules Are β2-Microglobulin-Associated, GPI-Anchored Glycoproteins That Do Not Require TAP for Cell Surface Expression
This study identified that mouse MILL1 and MILL2 are glycoproteins distinct from human MICA/B, primarily due to their association with β2-microglobulin and TAP-independent surface expression.
research N‑K GM SERIES: THE COMPLETE GEOMETRIC MEDICINE LIBRARY — From Discovery to Deployment: SELECTIVE‑ANTI‑BACTERIAL‑GM2, SELECTIVE‑ANTI‑PATHOGENIC‑FUNGI‑GM2, and the CMC Pocket Delivery System A Comprehensive Framework for Precision Antimicrobials — 1,000,000,000:1 Selectivity, Zero Ecological Harm, Free for Humanity
This publication presents a library of precision geometric medicines that reportedly kill harmful bacteria and fungi while sparing beneficial organisms, using a delivery system that targets pathogens specifically and avoids ecological harm.
research Preparation of Anticancer Extract
This study explored the antibacterial and wound-healing effects of an 80% methanol extract from Hibiscus micranthus leaves, finding it effective against several bacterial strains and beneficial for wound healing in rats.
research AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress Melanomagenesis
This study suggests that activating AMPK to phosphorylate ZDHHC13 may enhance MC1R function and reduce melanoma risk in individuals with red hair.
research A case of recalcitrant pediatric Vogt-Koyanagi-Harada disease successfully controlled with adalimumab
This case study reports that adding adalimumab to a 12-year-old VKH patient's treatment allowed for ocular inflammation remission, vision improvement, and corticosteroid tapering, suggesting escalation of immunosuppression may be critical in pediatric VKH cases.
research HYPOGLYCEMIC POTENTIAL OF HIBISCUS ROSA-SINENSIS AND MANGIFERA INDICA LEAVES BY IN VITRO METHODS
In this in vitro study, methanolic extracts of Mangifera indica and Hibiscus rosa-sinensis demonstrated significant inhibitory activity on α-amylase and α-glucosidase enzymes, suggesting their potential usefulness in diabetes management due to their comparable effects to the standard drug acarbose.
research High prevalence of poly cystic ovary syndrome among young Saudi medical students: an observational cross-sectional study
In this study, young female medical students at King Saud University reported a higher prevalence of physician-diagnosed PCOS compared to similar Western populations, and hirsutism was notably associated with the condition, highlighting the need for early screening and health education.
research DP18 A mimicker of melanoma on sun-exposed sites
In this report, two cases of melanocytic matricoma, a rare benign hair follicle lesion that mimics melanoma and basal cell carcinoma, were described and successfully treated with complete surgical excision. Histological analysis was crucial for differentiation from similar malignant lesions.
research 645 MIG6 is MEK-regulated and affects EGF-induced migration in mutant NRAS melanoma
This study found that in mutant NRAS melanoma, MEK inhibitors led to increased AKT signaling and reduced MIG6, a change that may enhance cell migration and invasiveness.
research Multifunctional Photoactive Hydrogels for Wound Healing Acceleration
This review discussed the potential of multifunctional photoresponsive hydrogels for wound regeneration, highlighting various types prepared with diverse photosensitizers and photothermal/photodynamic agents, and explored their role in modulating bacterial microenvironments to inhibit infection and promote healing.
research Case Report: 7 Year-Old Saudi Female with Monilethrix
This case report describes a 7-year-old female from the Middle East with monilethrix, highlighting the disease's rarity in this population, characterized by brittle, sparse hair and keratosis pilaris.
research 10. EVALUATION OF THE EFFICACY AND SAFETY FOR THE COMBINATION USE OF ORAL AND TOPICAL TRANEXAMIC ACID IN THE TREATMENT OF MELASMA AT HO CHI MINH CITY DERMATOLOGY HOSPITAL
In this study, oral and topical tranexamic acid significantly improved melasma symptoms in 28 female patients, with all showing over 25% improvement and 50% achieving good improvement, while 92.86% experienced no side effects, suggesting it is an effective and safe treatment.
research Food Deprivation-induced Expression of Minoxidil Sulfotransferase in the Hypothalamus Uncovered by Microarray Analysis
Food deprivation increases MST enzyme in the brain, possibly affecting energy balance.
research Hague (Hag): A New Mouse Hair Mutation With an Unstable Semidominant Allele
This study mapped a spontaneous mouse hair mutation, "hague," to keratin genes on chromosome 15 but found no gene mutations in hague mice.
research Long‐Term Management with Adipose Tissue‐Derived Mesenchymal Stem Cells and Conventional Treatment in a Dog with Hepatocutaneous Syndrome
The authors reported that a combination of amino acid and stem cell therapy may have extended survival in a dog with hepatocutaneous syndrome to 32 months post-diagnosis.
research Uncombable hair syndrome and beyond
This article presents an overview of uncombable hair syndrome, emphasizing its clinical and molecular characteristics and noting systemic manifestations such as neuropsychiatric, ophthalmic, and cardiopulmonary issues.
research Determination of Minoxidil by Bleaching the Permanganate Carrier Solution in a Flow-Based Spectrophotometric System
This study demonstrated that a flow injection method using potassium permanganate for detecting minoxidil provided accurate recoveries and agreed closely with HPLC results, showing potential for effective analysis of commercial samples.
research Preparation and Characterization of GHK-Cu Liposome and its Effects on Hair Growth in Mouse Alopecia Model
This study found that both GHK-Cu liposome and GHK-Cu promoted hair growth and increased VEGF expression in a mouse model of alopecia.
research A new locus for hereditary hypotrichosis simplex maps to chromosome 13q12.12∼12.3 in a Chinese family
This study identified a novel locus for hereditary hypotrichosis simplex on chromosome 13q12.12~12.3 in a four-generation Chinese family.
research Direct cellular reprogramming enables development of viral T antigen–driven Merkel cell carcinoma in mice
This study found that the development of Merkel cell carcinoma from hair follicles in mice can be driven by in vivo reprogramming with ATOH1 and relies on p53 loss for progression.