Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review summarizes current literature associating mitochondrial dysfunction with dermatologic issues like skin aging, hair loss, and poor wound healing, noting potential benefits in targeting mitochondrial components for treatments.

In this study, Nerium oleander extract demonstrated high effectiveness in killing Sarcoptes scabiei var. cuniculi mites in vitro, achieving up to 100% mortality in 8 hours, suggesting potential as a therapeutic method for scabies in rabbits.

This study found that hypoxia-preconditioned HF-MSC-derived exosomes improved therapeutic outcomes in models of ulcerative colitis, potentially through miR-214-3p-mediated pathways affecting mitochondrial function and inflammatory responses.

This review examines the role of androgens and androgen receptors in regulating glucose and lipid metabolism, focusing on their effects on mitochondrial content and function; it also discusses the sex-dimorphic influence of androgens and provides theoretical insights into their mechanisms.

This study identified novel mitochondrial DNA variations in PCOS patients from Pakistan, which may serve as genetic predisposition markers, highlighting especially the potential pathogenicity of frameshift mutations in the MT-ND2 gene.

Hair follicle stem cells and mitochondria are key for hair growth, and targeting their activity could lead to new hair loss treatments.

This study suggests that MPZL3, a mitochondrially localized protein, may play an integral role in regulating hair follicle cycles, with potential therapeutic implications for hair growth disorders if findings translate to humans.

This study suggests that targeting mitophagy to regulate mitochondrial dysfunction and inhibit inflammasome activation could offer a novel therapeutic approach for alopecia areata.

This study found that mitochondrial dysfunction in T cells led to defective hair follicle stem cell function and premature skin aging signs in a mouse model.

This study found that inhibiting the Mitochondrial Pyruvate Carrier in human hair follicles ex vivo activated the integrated stress response, affecting cell proliferation and metabolism.

This study found that mitochondrial dysfunction in the epidermis contributes to aging-related changes in hair follicles among mice, with aged mice showing reduced hair density and delayed regrowth, suggesting that maintaining mitochondrial function may help prevent age-related organ decline.

This study found that sodium butyrate, a metabolite from the HF microbiome, significantly delayed catagen onset and promoted key physiological processes in cultured human hair follicles.

Baricitinib reduces inflammation and mitochondrial damage in skin cells.

This study found that Substance P increased mitochondrial activity and biogenesis markers in cultured human scalp hair follicles, suggesting a novel link between stress-related neuropeptide signaling and hair follicle mitochondrial responses.

This study found that knocking out the Hars2 gene in mouse cochlear hair cells led to mitochondrial dysfunction and ROS stress, resulting in progressive hearing loss and differential effects on inner and outer hair cells.

This study found that MPZL3 plays a crucial role in regulating the hair cycle clock in mice, with its absence leading to accelerated hair follicle cycling and suggesting potential therapeutic pathways for alopecia treatment.

This study suggests that inhibiting PKC, similar to rapamycin treatment, can extend lifespan and reduce neurological symptoms and inflammation in mice with mitochondrial dysfunction, potentially involving the mTORC2 pathway.

The study reported that Demodex musculi infestation was notably higher in immunodeficient mice, while infested immunocompetent mice, particularly the BALB/c strain, showed increased IgE levels and developed alopecia over time.

This study found that patients with the MITF p.E318K variant are more likely to develop multiple primary melanomas and dysplastic nevi with uncommon dermoscopic patterns compared to non-carriers.

This study suggests that mitochondrial dysfunction might contribute to the pathogenesis of Lichen planopilaris by triggering a metabolic shift that leads to chronic inflammation and hair follicle damage.

Mitochondria may influence how cells respond to radiation, affecting nearby non-irradiated cells.

This study found that one month of diabetes altered neuroactive steroid levels and associated mechanisms in the hippocampus and cerebral cortex of an experimental rat model.

This study suggests that specific mutations in the MFN2 gene, including the p.Arg707Trp allele, can result in tissue-selective mitochondrial dysfunction leading to excessive upper body fat growth and low leptin levels.

This chapter discusses charnolopharmacotherapeutics for various medical conditions and suggests antioxidant-loaded nanoparticles may improve treatment by enhancing central nervous system delivery and inducing charnolophagy.

This study identified 92 novel regulators of melanogenesis, highlighting Aldehyde dehydrogenase 1A1 as a potential target for developing new treatments for hyperpigmentation disorders like melasma.

This study identified ALDH1A1 as a regulator of melanogenesis and suggests its inhibition, through agents like cyanamide, may be a promising therapeutic approach for treating hyperpigmentation disorders such as melasma.

This article discusses the various skin side effects associated with targeted cancer therapies like tyrosine kinase inhibitors and EGF-R inhibitors but provides no new clinical findings.

This study found that mrp/plf-mRNA expression in murine skin increases in response to different tumor promoters, suggesting its potential as a short-term biomarker for chemical carcinogenesis.

This study suggests that Demodex mites might universally inhabit adult humans, with a phylogenetic analysis indicating potential undiscovered lineages of the D. brevis species based on geographic differences.

In this case study, electron microscopy revealed that harlequin ichthyosis involves giant mitochondria in keratinocytes and abnormal lamellar granule development, which may contribute to pathogenesis through altered lipid metabolism.