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This review provides an overview of how advancing imaging technologies, such as tissue clearing and intravital microscopy, are enhancing our understanding of tumor architecture and interactions between cancer cells and the tumor microenvironment, aiding both fundamental cancer research and the development of therapies.

This study reveals that basement membrane composition and structure in mouse hair follicles are specialized for distinct inter-tissue interactions, with laminin α5 being essential for maintaining these interfaces.

This review discusses the fundamental features of hair follicle biology and its clinical importance, but it reports no new clinical results.

This study found that MAP-2 is intensely expressed in the companion layer of the hair follicle, suggesting its potential importance to follicle integrity and possible involvement in some types of alopecia.

This study describes the use of a genetically engineered mouse model, mTurquoise2-Col4a1, to fluorescently label collagen IV and observe basement membrane dynamics during skin development, revealing its stability and pliability during rapid growth phases.

In this study, the researchers found that trichoscopy can effectively visualize scalp micropigmentation, identified by homogenous, grey to black circular dots similar to closely cut hair, potentially reducing the need for invasive procedures.

African hair is more fragile due to its unique shape and internal structure.

This study found that sonography and electron microscopy revealed distinct abnormalities in hair follicle morphology in patients with androgenetic alopecia, which may aid in diagnosing and managing the condition.

This study used advanced analytical techniques to reveal that proteins and lipids are distributed unevenly in hair, with distinct structural differences depending on their location within the fiber.

This essay reviews the potential of protein microarrays in proteomics and diagnostics, highlighting no new clinical results but emphasizing the need for advanced high-quality proteins and antibodies.

This article describes a method using the CUBIC protocol to clarify and visualize molecular and cellular interactions in mouse skin biopsies at single cell resolution, but does not provide new biological findings.

This paper reviews how studying the microbiome of the freshwater polyp Hydra can inform new, microbiome-targeting therapies for human hair follicle and skin diseases; it presents no new experimental findings.

This study suggests that miniaturization in pattern hair loss may occur abruptly and can be reversed with treatment, as supported by histologic evidence in finasteride-responsive patients.

This review discusses the use of hair microscopy in diagnosing hair-related conditions, highlighting techniques and common applications, but presents no new experimental results.

This study found that miniaturization of hair is present in some women with androgenetic alopecia, but diagnosis may also be based on differences in hair shaft diameter between scalp regions.

In this study, the researchers found that a manual micrometer caliper is a reliable tool for planning hair transplant surgery and accurately measures the short axis of the hair shaft.

In this study, researchers used atomic force microscopy to capture and analyze morphological changes in the surface of healthy hair, identifying features such as pitting and rod-shaped macro-fibrillar elements, which could inform future research on hair conditions and care.

In this study, researchers successfully constructed a high-precision three-dimensional model of human skin dermis, revealing a detailed analysis of dermal porosity and pore diameter distribution, which can aid the development of biomimetic tissue-engineered skin.

This study explored the use of "microfollicles," a human hair follicle organoid model, as an in vitro tool for testing hair-growth substances, finding up to 75% overlap in gene expression changes with human clinical biopsy responses to minoxidil, indicating its potential for pre-clinical substance testing.

In this study, researchers created a comprehensive transcriptome map of human hair follicle compartments, identifying compartment-specific genes and providing a resource for potential therapeutic interventions.

This review focuses on hydrogel microsphere-mediated strategies to improve organoid culture by addressing deficiencies in extracellular matrix organization, potentially enhancing the physiological accuracy and clinical translatability of osteomuscular in vitro models as reported in this study.

Three new techniques simplify and improve the preparation of tissue samples for skin cancer surgery.

This article describes the structure of ovine interdigital sinuses using scanning electron microscopy, highlighting features such as dense secretory material, hair presence, and classical apocrine secretion characteristics.

This article describes the immunofluorescence tomography method to achieve high-resolution 3-D reconstruction of epithelial tissues and reports no clinical results.

This study used rapid-freezing immunocytochemistry to successfully map the ultrastructural localization of hair keratins in human scalp hair, primarily finding them in macrofibrils in the cortex and endocuticle.

This study examined the unique structural features of sinus hair follicles in the shrew Sorex unguiculatus, which suggest a specialization for vibration sensing.

In this study, researchers developed a custom-designed 3D-printed microscope stage insert for inverted confocal microscopes, enhancing the accessibility of long-term intravital imaging of live cell dynamics in live transgenic mice, particularly in the skin.