research Disruption of Tubular Flcn Expression as a Mouse Model for Renal Tumor Induction
Disrupting the Flcn gene in mice causes early kidney cysts and tumors, which can be treated with rapamycin.
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research Current Protocols: Alopecia Areata Mouse Models for Drug Efficacy and Mechanism Studies
The C3H/HeJ mouse model is useful for studying and testing treatments for alopecia areata.
research Quantitative Analysis of Hair Luster in a Novel Ultraviolet-Irradiated Mouse Model
UV exposure reduced hair shine in mice, but minoxidil helped restore it.
research The Effect of Testosterone, Cyproterone Acetate, and Minoxidil on Hair Loss in Androgenetic Alopecia Mouse
The mouse model could be useful for baldness research and testing treatments like testosterone, cyproterone acetate, and minoxidil.
research Clinical Snippets: Discoveries in Dermatology and Related Fields
Topical Imiquimod may fight vascular tumors by affecting blood vessels or the immune system, low iron might be linked to some hair loss, removing the top skin layer helps vitamin C get in, genetic testing helps diagnose skin conditions, and too much iron could worsen skin inflammation.
research Protein Kinase C Downregulation Upon Rapamycin Treatment Attenuates Neuroinflammation and Mitochondrial Disease
Rapamycin treatment helps reduce brain inflammation and symptoms of mitochondrial disease by blocking specific pathways in mice.
research Finding Models for Skin Diseases: Successes and Failures
The document concludes that while finding animal models for the skin disease Hidradenitis suppurativa is challenging, certain mouse mutations may provide useful insights for research and drug testing.
research Bioengineering a 3D Integumentary Organ System from iPS Cells Using an In Vivo Transplantation Model
Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.
research Follicular Delivery of a Novel Peptide Therapeutic for the Treatment of Androgenic Alopecia
A new peptide, murikal/SPR4, was found to significantly increase hair growth in mice, and its liposomal topical formulations enhanced hair growth more than commercial products. However, results on human scalp skin were unclear, needing more tests.
research Hair Morphogenesis In Vitro: Formation of Hair Structures Suitable for Implantation
Scientists created early-stage hairs from mouse cells that grew into normal, pigmented hair when implanted into other mice.
research Poly(γ-Glutamic Acid)/Chitosan Hydrogel Nanoparticles for Effective Preservation and Delivery of Fermented Herbal Extract for Enlarging Hair Bulb and Enhancing Hair Growth
The nanoparticles improved hair growth and enlarged hair bulbs.
research Animal Models of Psoriasis: What Can We Learn from Them?
Rodent models helped understand psoriasis but none perfectly replicated the disease.
research Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata
Alopecia areata can be triggered by specific immune cells without genetic or environmental factors.
research Follicular Dermal Papilla Structures by Organization of Epithelial and Mesenchymal Cells in Interfacial Polyelectrolyte Complex Fibers
Scientists created 3D hair-like structures that could help study hair growth and test treatments.
research The Patch Assay Reconstitutes Mature Hair Follicles by Culture-Expanded Human Cells
The patch assay can create mature hair follicles from human cells and may help in hair loss treatments.
research Putting the Human Hair Follicle Cycle on the Map
The research created a model to understand human hair growth cycle, which can help diagnose and treat hair growth disorders and test potential hair growth drugs.
research Understanding Cellular and Molecular Responses in the Treatment of Pediatric Lymphatic Anomalies
Sirolimus and propranolol may reduce abnormal cell growth and improve lymphatic malformations in children.
research On Photo-Stability of Oxybenzone
Estrogen receptors may not affect mouse hair growth as previously thought, and oxybenzone in sunscreen is stable in sunlight.
research Loss of Msx2 Function Down-Regulates the FoxE3 Expression and Results in Anterior Segment Dysgenesis Resembling Peters Anomaly
Loss of Msx2 function causes eye development issues similar to Peters anomaly.
research Cortexolone 17a-Propionate: A New Antiandrogen Acting on Hair Dermal Papilla Cells for the Treatment of Androgenic Alopecia
Cortexolone 17a-propionate may be an effective new treatment for hair loss.
research Animal Models of Psoriasis: Highlights and Drawbacks
Animal models help study psoriasis but have limitations and don't fully mimic the human disease.
research Touch Receptors Undergo Rapid Remodeling in Healthy Skin
Touch sensitivity in mouse skin decreases during hair growth due to changes in touch receptors.
research Graphene Oxide–IPDI–Ag/ZnO@Hydroxypropyl Cellulose Nanocomposite Films for Biological Wound-Dressing Applications
The new nanocomposite films are stronger, protect against UV, speed up wound healing, and are antibacterial without being toxic.
research Failure of Topical Estrogen Receptor Agonists and Antagonists to Alter Murine Hair Follicle Cycling
Topical estrogen treatments did not change hair growth in certain mouse strains, questioning previous findings on their role in hair growth control.
research Hair Growth-Promoting Activity of Components Derived from Sweet Potato Shochu
Sweet potato shochu oil and its components may effectively promote hair growth.
research Experimental Assessment of 3-Meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-Alpha-Reductase Inhibitors in Silico and in Vivo Models
The new compound is a promising, less toxic alternative to finasteride for treating prostate issues.
research Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels
Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.
research Biological Actions of Oligomeric Procyanidins: Proliferation of Epithelial Cells and Hair Follicle Growth
Oligomeric procyanidins may help hair grow by affecting cell growth and the hair growth cycle.
research Oxygen, Metabolism, and Regeneration: Lessons from Mice
Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.
research Epimorphic Regeneration in Mice Is p53-Independent
Mice can regenerate ear tissue without the p53 protein.