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New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

Systemic glucocorticosteroids are a primary treatment for various skin conditions but require careful management due to potential side effects and relapses.

Epilepsy and certain epilepsy drugs can lead to reproductive problems in women, but changing medication might improve these issues.

Insulin-sensitizing drugs like metformin can help with ovulation, weight loss, and lower testosterone in some women with PCOS.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

The document concludes that various drugs can manage symptoms and metabolic issues in women with PCOS.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

A Japanese patient with IFAP syndrome had a severe MBTPS2 gene mutation but showed milder symptoms than previously observed cases.

LEF1 is essential for the development of airway glands and is regulated by the Wnt/ß-catenin pathway.

Testosterone may worsen hair loss by affecting hair growth signals, while different prostaglandins can either hinder or promote hair growth.

Acne is a common skin condition linked to diet, hormones, and genetics, and early treatment can prevent scarring.

The GH-IGF-I axis is likely involved in the hormonal imbalances seen in non-obese women with functional hyperandrogenism.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

DNA methylation is essential for skin and hair follicle development, and could be a target for treating skin diseases.

Genetic testing confirmed a rare skin disorder in a young girl, which improved with zinc supplementation.

The man's fatigue and erectile dysfunction were improved by treating his obesity-related low testosterone without needing testosterone replacement.

A certain gene variation is linked to a higher risk of polycystic ovarian syndrome in South Indian women.

Insulin resistance is linked to PCOS and can lead to other health issues, but treatments like metformin can help manage symptoms.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

Spironolactone treatment increases the amount of testosterone available in the body.

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.

Fibromodulin might help reduce scarring if increased in adult wounds like in fetal skin that heals without scars.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.