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The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

Excess androgens may cause PCOS, not just be a symptom.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

Bariatric surgery improves skin conditions and metabolism but may cause nutritional deficiencies and hair loss.

Late diagnosis of congenital adrenal hyperplasia can greatly affect physical development, gender identity, and sexual health.

The GH-IGF-I axis is likely involved in the hormonal imbalances seen in non-obese women with functional hyperandrogenism.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

High BMI worsens hair growth in women with PCOS.

The 2018 guideline for PCOS suggests new diagnostic criteria and treatments, but recognizes the need for more research.

Bariatric surgery improves ovulation rates in women with PCOS and obesity better than medical therapy.

Long-term high testosterone levels can improve bone density and reduce body fat but may increase the risk of prostate cancer and high blood pressure.

Women with PCOS have more Bifidobacterium in their gut compared to those without PCOS.

Treating sleep apnea in young obese women with PCOS can improve heart health and insulin sensitivity.

Eating less and exercising more, with personalized diet plans and realistic goals, can lead to weight loss and better health, but more research is needed for long-term success.

Women with PCOS and polycystic ovaries have higher male hormone levels and more insulin resistance, especially if they are overweight.

Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.

Bergamot may improve heart health, skin conditions, and mood, but more research is needed to confirm these benefits.

Metformin helps manage diabetes, PCOS, and weight in kids but needs more research for long-term safety.

Treating early puberty with hormone therapy may increase the risk of polycystic ovary syndrome in adults.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

Higher testosterone levels can increase the risk of certain diseases like type 2 diabetes in women and prostate cancer in men, but can also protect against autoimmune diseases and hair loss. It also affects body fat and bone density.

Polycystic ovary syndrome and iron overload share similar symptoms and can be potentially treated with blood removal, diet changes, and probiotics.

Women with Polycystic Ovary Syndrome (PCOS) have lower levels of a substance called DIAPH1 in their blood, which is linked to changes in sugar metabolism and insulin resistance.

Older men with low levels of a testosterone byproduct had a higher chance of developing an irregular heartbeat.

Testosterone therapy may slightly increase sexual desire in women with HSDD but lacks broad recommendation due to safety concerns and limited approval.

The 2023 guideline advises a detailed approach for PCOS, focusing on early detection, lifestyle and medical treatments, and managing health risks.

The guideline refines PCOS diagnosis, promotes a healthy lifestyle, reviews treatments, and stresses long-term follow-up.

The document concludes that more research is needed to fully understand the causes of PCOS.

Activating TLR5 in the gut can extend lifespan and improve health in aged mice.