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This review discusses the role of mechanical forces in skin homeostasis and disease development, including their impact on conditions like keloids, androgenetic alopecia, and acral melanoma, and reports no clinical results; the authors propose modifying these forces as a potential therapeutic strategy.

This study found that Gynostemma pentaphyllum hydrodistillate and Damulin B exert significant anti-photoaging effects in UVB-irradiated models by reducing oxidative stress, improving ECM integrity, and enhancing skin hydration and elasticity.

This study found that DHEA along with osteogenic induction medium significantly promotes the osteogenic differentiation and proliferation of human bone marrow mesenchymal stem cells from older individuals.

This study defines two types of RDEB wounds, chronic open and recurrent, and finds that patient self-reports on wound size correlate well with investigator measurements when complemented by serial photography.

The study reported a significant genotype–phenotype correlation in prepubescent males with XLHED, particularly in the severity of skin and hair manifestations between those with different EDA mutations.

In this study using a mouse model, researchers found that DNA methylation of the miR-365-1 promoter plays a role in reducing apoptosis in hair follicle stem cells during chemotherapeutic alopecia.

This review examines the complex role of the Ectodysplasin-A pathway in skeletal morphogenesis, emphasizing its interaction with other key signaling pathways, and reports no new experimental findings.

In this comprehensive review, researchers examine the p63 gene's crucial role in skin development and pathology, highlighting its regulation of cell processes and its potential therapeutic implications for disorders like ectodermal dysplasia.

This study found that Hairless (HR) and putrescine form a negative regulatory network that impacts epidermal homeostasis and hair follicle cycling, linked to the MYC superfamily's regulation of ODC expression.

This study concludes that anti-androgenic chemicals causing short anogenital distance in male fetuses also induce a feminized transcriptional profile in the perineum, implicating Wnt and estrogen signaling in the process.

This study reported that mSKPs and DMSCs share similarities in biological characteristics but exhibit distinct transcriptome profiles, with mSKPs being more immune-related and DMSCs more associated with differentiation and disease pathways.

This phase I study determined that a combination of oral SU-014813 and docetaxel is a feasible treatment with a manageable safety profile and potential anti-tumor activity, particularly noted in melanoma and GIST patients.

This review discusses the development of human skin with a focus on desmosomes, noting the challenges of translating animal model findings to humans due to species differences and limited human sample access.

This review examines microneedle patches for drug delivery, detailing their designs, materials, manufacturing methods, and potential advantages, but reports no new clinical results.

This study observed defects in hair cuticle cross-linking in some, but not all, mouse mutants with sparse or structurally unsound hair.

This review in SEDA Volume 40 summarizes new adverse reaction data for diuretics published in 2017, highlighting specific risks such as fractures with loop diuretics and hyperkalemia with spironolactone.

This study found that a spontaneous deletion in the Dsg3 gene of mice leads to hypomorphic desmoglein 3 expression, resulting in severe immunodeficiency, cyclic hair loss, and wasting disease, without causing the blistering typical of pemphigus vulgaris.

In this study, different types of catagen in the C57BL/6 mouse model exhibited varying effects on hair follicle melanocytes and melanin distribution, with spontaneous and dexamethasone-induced catagen showing pigment incontinence, while cyclophosphamide-induced catagen retained dendritic melanocytes but increased ectopic melanin.

This study found that in patients with severe aortic valve stenosis, higher serum dihydrotestosterone levels were associated with increased myocardial hypertrophy, fibrosis, and reduced left ventricular function.

This study identified novel compound heterozygous mutations in the DSG4 gene in a Japanese patient with congenital hypotrichosis, suggesting overlap between localized autosomal recessive hypotrichosis and monilethrix.

This editorial discusses the potential progression of voiding symptoms over time in men, focusing on benign prostatic hyperplasia, but reports no new research findings.

This review discusses the role of norepinephrine release and protein kinase C activation in the development of benign prostatic hypertrophy, suggesting potential targets for new therapies, but it reports no new clinical results.

This study synthesized and evaluated five 6-mercaptopurine derivatives for anticancer activity against three cancer cell lines, detailing the promising results of compound 1.

This study developed a bifunctional sodium hyaluronate microneedle patch incorporating glycyrrhizin-loaded dutasteride micelles and mesoporous polydopamine nanoparticles, which effectively inhibited DHT and reduced ROS in hair follicle cells, resulting in significantly accelerated hair growth in vitro and in vivo.

This study found that mEGF ethosomal delivery systems mainly penetrated mice skin through the pilosebaceous unit and successfully induced hair follicles to transition from the telogen to anagen phase.

This study reports that a homozygous A1103G mutation in DSG 4 is responsible for localized autosomal recessive hypotrichosis in a 2-year-old Chinese girl, resulting in reduced DSG 4 expression and hair defects.

This study found that knocking out the Hars2 gene in mouse cochlear hair cells led to mitochondrial dysfunction and ROS stress, resulting in progressive hearing loss and differential effects on inner and outer hair cells.

This article discusses a novel mutation in the FERMT1 gene identified in a Spanish family with Kindler’s syndrome but reports no new clinical results.

Mycophenolate mofetil improved skin condition in a man with nephrogenic fibrosing dermopathy.

This review discusses the evolution and development of smart and multifunctional microneedles, highlighting their potential future importance in medical applications, but it reports no new experimental results.