109 citations
,
October 2007 in “Journal of pineal research” This study suggests that melatonin plays a role in hair follicle function by modulating growth and pigmentation, and it may act as a protective agent in active hair growth phases.
91 citations
,
July 2010 in “Tissue Engineering Part A” This study found that low oxygen conditions and ECM degradation products increased the proliferation and migration of perivascular stem cells without altering their phenotype, suggesting potential roles in tissue repair.
82 citations
,
February 2017 in “Cold Spring Harbor Perspectives in Biology” The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.
73 citations
,
March 2017 in “Scientific Reports” This study demonstrates that bioengineered tooth germ autologously transplanted in a postnatal canine model can achieve functional tooth restoration, suggesting its potential for future clinical regenerative medicine.
64 citations
,
March 2017 in “Nature communications” This study identified 63 genetic loci associated with male-pattern baldness, uncovering genes and pathways that may help develop treatments and suggesting its connection to other human conditions.
61 citations
,
June 2018 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that light stimulation of intrinsically photosensitive retinal ganglion cells in the eyes can activate hair follicle stem cells through a neural circuit involving the sympathetic nervous system.
60 citations
,
June 2019 in “Ageing Research Reviews” This review discusses the potential of adipose-derived tissue components like nanofat and stem cells for aesthetic rejuvenation, covering their use in hair growth, scar reduction, and more, without reporting new clinical results.
57 citations
,
February 2013 in “Journal of Dermatological Science” This article reviews methods to enhance epithelial–mesenchymal interactions for hair follicle bioengineering but does not present new experimental results; it emphasizes optimizing combinations for successful regeneration.
52 citations
,
October 1999 in “Developmental Dynamics” This study found that the hairless gene in mice has a more extensive role in development than previously thought, as indicated by its expression in various tissues and associated abnormalities in hr/hr mutants.
47 citations
,
May 2012 in “Wiley Interdisciplinary Reviews-Developmental Biology” This article reviews the generation of complex integument patterns through genetic, chemical, and environmental influences, with applications in tissue engineering, but reports no new experimental results.
47 citations
,
August 2000 in “Endocrine Reviews” This review discusses idiopathic hirsutism, potential underlying mechanisms, and various therapeutic approaches without providing new clinical results, and emphasizes the need for further research on well-defined patient groups.
47 citations
,
July 2013 in “Pharmacological Reviews” This review discusses the role of pharmacological sciences in advancing regenerative medicine technologies but reports no new experimental findings; the authors advocate for increased pharmacologist involvement to drive innovations.
44 citations
,
January 2005 in “Dermatology” This article reviews the clinical and diagnostic features of hair shaft disorders, emphasizing the role of structured patient assessments and the avoidance of hair trauma, but reports no new results.
39 citations
,
January 2019 in “Cells” This review discusses the molecular mechanisms of Hutchinson-Gilford progeria syndrome and evaluates current research trends, available mouse models, and prospects for developing therapies, but reports no new clinical findings.
31 citations
,
April 1999 in “Dermatologic Clinics” This article reviews the use of the Nd:YAG laser for hair removal and reports no new research findings.
30 citations
,
April 2017 in “Experimental Dermatology” This review explores the role of hair follicle dermal stem cells in skin regeneration and restorative therapies, but it reports no new experimental results.
30 citations
,
March 2010 in “European Journal of Dermatology” This article discusses hair loss in postmenopausal women as often being multifactorial, reviewing various conditions affecting this group, but reports no new research findings.
30 citations
,
October 2016 in “Current research in translational medicine” This essay reviews the role of human scalp hair follicles in the "brain-skin connection," highlighting their dual function as targets and sources of neurohormones, without reporting new experimental results.
29 citations
,
December 2012 in “Fibrogenesis & Tissue Repair” This review discusses the roles of tissue-specific and mesenchymal stromal cells in tissue repair and reparative disorders, highlighting potential therapeutic targets for muscle, heart, and lung tissues.
27 citations
,
March 2018 in “Biomaterials” This study found that a cocktail of three proteins from embryonic skin can enable adult fibroblasts to regenerate hair follicles by altering gene expression and activating regenerative signaling pathways.
27 citations
,
December 2013 in “Endocrinology” This study established a mouse model for Cushing's syndrome due to a specific Crh mutation, which may help explore the effects of glucocorticoid excess and evaluate treatments for corticosteroid-induced osteoporosis.
26 citations
,
December 2016 in “Pharmacology & Therapeutics” This review discusses the paracrine properties of cardiac stem cells and pericytes in regenerative medicine for ischaemic diseases and reports no new clinical results.
25 citations
,
September 2006 in “Birth Defects Research” This article discusses various skin pattern formations, their molecular mechanisms, and highlights the need for further understanding to connect molecular biology with organism phenotypes, without providing new clinical findings.
23 citations
,
June 2015 in “Oncology Letters” This study reported that adipose-derived stem cell-conditioned medium demonstrated anti-tumorigenic effects on B16 melanoma cells both in vitro and in vivo, indicating potential for future melanoma treatment.
22 citations
,
June 1980 in “International Journal of Dermatology” The document concludes that correct diagnosis of alopecia types is crucial, scalp biopsies are important, and more research is needed.
18 citations
,
January 2008 in “Journal of The American Academy of Dermatology” This study found that the proteins GDNF, NTN, GFRα-1, GFRα-2, and c-Ret are differentially expressed during various stages of the human hair follicle cycle, with potential implications for hair biology.
16 citations
,
April 1978 in “Genetics Research” This study found that asebic mice exhibit abnormal sebaceous gland differentiation and insufficient sebum production due to defective regulation of cell processes, despite possessing normally developing sebaceous glands initially.
16 citations
,
January 2007 in “Dermatology” This review summarizes recent progress in human hair follicle bulge cell research, particularly the characterization and isolation of these stem cells, but reports no new experimental results.
14 citations
,
October 2020 in “Natural Products and Bioprospecting” This review discusses current topical treatments, natural products, and complementary therapies for androgenetic alopecia, but it reports no new clinical results.
13 citations
,
June 2020 in “Scientific reports” In this study, melatonin administration enhanced various cellular and structural features of the scrotal skin in Soay rams, including increased thickness, cell count, and gland activity.