January 2021 in “Journal of clinical and cosmetic dermatology” This review highlights the role of the skin's photosensory system in mediating responses to UVA radiation, contributing both to immediate protective effects and to broader circadian and seasonal adaptations, but reports no new experimental results.
14 citations
,
October 2020 in “Scientific reports” This study found that ATM protein plays a crucial role in protecting human hair follicle melanocytes from oxidative stress, which is linked to the greying of hair.
2 citations
,
January 2002 in “Clinics in Dermatology” This review details the characteristics, associations, and differential diagnoses of vitiligo and reports no new clinical findings.
This chapter reviews recent developments in vitiligo research, highlighting the role of melanocyte stem cell differentiation and oxidative stress in its management, but reports no new clinical results.
114 citations
,
April 2004 in “International Journal of Dermatology” Postinflammatory hyperpigmentation causes dark skin patches and needs personalized treatment.
September 2017 in “Journal of Investigative Dermatology Symposium Proceedings” This report highlights four cases where squamous cell carcinoma was misdiagnosed in individuals with darker skin, emphasizing the challenges in accurate diagnosis for this population.
May 2015 in “Journal of Investigative Dermatology” Melanoma risk tools need improvement, a gene mutation causes a hair disorder that might be treated by managing cell stress, a potential therapy for a skin-ear disorder involves blocking cell channels, skin wrinkling may indicate lung aging regardless of smoking, and oxidative stress might contribute to common baldness.
This study suggests that incorporating exogenous melatonin in the treatment of certain skin disorders, like psoriasis and eczema, can improve treatment efficiency, normalize immune parameters, and reduce disease relapses.
April 2024 in “Pigment cell & melanoma research” This study explored the diversity of melanocyte stem cell subpopulations in the hair follicles of adult female mice and identified novel groups with distinct immune privilege regulation, suggesting a heterogeneous landscape that future research should consider.
November 2022 in “Indian Journal of Dermatology/Indian journal of dermatology” In this case report, a 17-year-old male on sodium valproate therapy developed rare longitudinal melanonychia, suggesting sodium valproate can induce nail pigmentation as a side effect.
9 citations
,
July 2012 in “Dermatitis” Hair dye with para-phenylenediamine can cause skin depigmentation.
3 citations
,
January 2019 in “Advances in stem cells and their niches” This review discusses the role of dermal papilla cells in hair follicle morphogenesis and regeneration and reports no new results; the authors emphasize the importance of these cells in hair growth and pigmentation regulation.
27 citations
,
July 1983 in “Journal of Investigative Dermatology” 25 citations
,
May 1995 in “Journal of the American Academy of Dermatology” This article reports two new cases of erythromelanosis follicularis faciei in women and includes a literature review on this rarely diagnosed condition.
9 citations
,
June 1959 in “Archives of dermatology” This article discusses the importance of integrating clinical observations with laboratory research, emphasizing the need for clinicians to collaborate with researchers to address medical problems.
96 citations
,
January 1997 in “Clinics in Dermatology” This study found that G protein-coupled estrogen receptor enhances melanin synthesis in melanoma cells through cAMP-PKA-MITF-TYR signaling, suggesting its potential as a drug target for chloasma treatment.
September 2006 in “Experimental Dermatology” This review discusses the genetic pathways involved in melanoma and suggests that targeting these pathways with pharmacological inhibitors may provide a new therapeutic approach, though clinical results have been disappointing so far.
April 2015 in “한국생물공학회 학술대회” Finasteride reduces melanin production in skin cells.
33 citations
,
January 2015 in “Journal of Ginseng Research” This study found that ginsenoside Rg3 significantly inhibited melanogenesis in human melanocytes and B16F10 cells by activating the ERK pathway, suggesting potential as a skin-whitening agent.
3 citations
,
January 2021 in “Skin appendage disorders” This study concluded that hair pigmentation, as measured by eumelanin-to-pheomelanin ratio, is not a risk factor for developing alopecia areata when compared to androgenetic alopecia patients.
82 citations
,
January 1997 in “Forensic science international” This article presents a biochemical model to explain how drug molecules are incorporated into hair, highlighting factors such as drug melanin affinity and the role of physico-chemical properties.
1 citations
,
April 2025 in “Pigment Cell & Melanoma Research” This article reviews the underlying mechanisms of segmental vitiligo with white hair, focusing on skin and hair follicle melanocytes, and proposes potential targets for treatment, highlighting neuroendocrine factors as possible contributors to the condition.
1 citations
,
June 2025 in “Pigment Cell & Melanoma Research” This literature review reports that mutations in the SASH1 gene are linked to different pigmentation disorders, including dyschromatosis universalis hereditaria and lentiginosis. It further suggests SASH1's significant role in melanocyte processes and its potential as a target for developing treatments for these conditions.
1 citations
,
January 2009 in “Elsevier eBooks” This review discusses the mechanisms of laser and IPL hair removal, particularly for darker skin types, and reports no new findings, highlighting potential adverse effects like pigmentation changes or scarring with improper use.
28 citations
,
December 2019 in “Skin appendage disorders” This review discusses medication-induced gray hair repigmentation, highlighting that certain anti-inflammatory drugs and melanogenesis stimulators can cause diffuse repigmentation, though evidence remains low-quality and these medications are not currently indicated for this purpose.
1 citations
,
July 2025 in “Frontiers in Genetics” In this study, researchers classified melanomas by filaggrin expression levels and found that in filaggrinHigh melanomas, there are significant changes in FGFR signaling and impaired GNA14 and Th1 signatures, linked to genetic and immune alterations associated with pruritus.
4 citations
,
August 2017 in “International journal of molecular sciences” This study observed two cases of pigmented epithelioid melanocytoma suggesting potential differing origins: one from a hair follicle's outer root sheath and another from an intradermal nevus.
5 citations
,
May 2018 in “Cancer Cell” This study found that melanoma cells develop resistance to therapies through dedifferentiation but become vulnerable to ferroptotic cell death, suggesting a potential therapeutic approach to target resistant forms of melanoma.
3 citations
,
October 2020 in “Journal of Investigative Dermatology” This study established that the Dct::CreERT2 mouse line is effective for targeting and studying adult melanocyte stem cells, contributing to the understanding of melanocyte biology and hair pigmentation.
1 citations
,
November 2024 in “Life” In this study, Desmodesmus pannonicus water extract demonstrated significant antioxidative properties, inhibited melanin production, promoted wound healing in human keratinocyte cells, and showed potential for hair growth enhancement in human follicle dermal papilla cells, suggesting its promise for future dermatological applications.