Filaggrin High Melanomas Exhibit Active FGFR and Allergic Signatures With Impaired GNA14 and Th1 Signatures
July 2025
in “
Frontiers in Genetics
”
Studysummary In this study, researchers classified melanomas by filaggrin expression levels and found that in filaggrin<sup>High</sup> melanomas, there are significant changes in FGFR signaling and impaired GNA14 and Th1 signatures, linked to genetic and immune alterations associated with pruritus.
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