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The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.

A young woman's symptoms suggested PCOS, but tests and surgery confirmed and treated a rare ovarian tumor, resolving her condition.

A male with aromatase deficiency improved bone health with estradiol treatment.

The document concludes that managing female hyperandrogenism requires a combination of identifying the cause, lifestyle changes, medication, and cosmetic treatments.

STIM1 is essential for sweat secretion.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Insulin resistance is significantly linked to a higher risk of depression in women with PCOS.

Testosterone in older women can increase bone density, muscle mass, fat mass, improve memory, and boost libido, but may cause nipple color changes.

Repeated dyeing and shampooing cause hair color loss and damage.

Higher DHT levels are linked to worse heart changes in severe aortic valve stenosis patients.

A woman's rare benign tumor that released both cortisol and testosterone was successfully removed, improving her health.

Ovarian vein sampling helped diagnose rare ovarian tumors causing high testosterone, and surgery to remove the tumors lowered the testosterone levels.

Postmenopausal hyperandrogenism, a condition with symptoms like increased hair growth and acne, is usually caused by PCOS but can also be due to other factors. It's diagnosed by checking testosterone levels and treated either by removing the adrenal tumor or through antiandrogen therapy.

Nanoparticle-based drug delivery to hair follicles is more effective when tested under conditions that match skin behavior.

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Mothers have more hair proteins than their children, with age-related differences in protein patterns, and some proteins in hair could indicate early childhood development.

Annurca apple extract promotes hair growth by changing hair follicle metabolism to boost keratin production.

The document summarizes medical findings on topics like heart rhythm treatment, sleep apnea therapy, and various health conditions and treatments.

Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

Androgens play a role in female sexual function, and testosterone therapy can help women with low sexual desire, but more research is needed on treatments and long-term safety.

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.

Pyrene excimer nucleic acid probes are promising for detecting biomolecules accurately with potential for biological research and drug screening.

Autophagy is crucial for normal sebaceous gland function and sebum composition.

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

Aging makes hair thinner and rougher, with less clear edges.

Changing the diagnosis criteria for PCOS might miss women at risk for related health issues.

Dutasteride may help reduce brain plaque linked to Alzheimer's by affecting cell energy structures and waste removal.