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New liposome treatment successfully delivers CRISPR to deactivate a key enzyme in androgen-related disorders.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Male androgenetic alopecia involves hair follicle miniaturization due to DHT, with potential treatments using inhibitors and blockers.

Tributyltin exposure causes sex changes, sterilization, and decline in the snail Ocinebrina aciculata, risking its extinction.

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.

Male pattern baldness involves hormone-related hair thinning, shorter hair, and inflammation.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.

The conclusion is that tritium-labeled testosterone metabolites can be made and are better converted into dihydrotestosterone in skin cells than in prostate tissue.

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

AGA in children needs careful diagnosis due to low androgen levels and possible other causes.

Individuals with male pseudohermaphroditism often do better raised as females with early surgery.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.

Five new mutations in the androgen receptor gene were found, helping to understand androgen insensitivity syndrome better.

Fibroblasts help understand androgen resistance at the cellular level.

The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.

Finasteride safely lowers DHT levels without affecting testosterone.

Dutasteride 0.5 mg daily improves hair growth safely in men with hair loss.

Men with coeliac disease may have hormone imbalances that could affect sexual function, but these can improve with better gut health.

Genetics and hormones cause hair loss; finasteride treats it safely.

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

DHT, a testosterone byproduct, causes male pattern baldness.

Men with enlarged prostates often have more severe baldness.

Men with male-pattern baldness have more androgen receptors in their scalp's oil glands, which may contribute to hair loss.