18 citations,
October 2021 in “Frontiers in Physiology” Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.
17 citations,
January 2013 in “Dermatologic Clinics” The conclusion is that accurate diagnosis of different types of hair loss requires careful examination of tissue samples and understanding of clinical symptoms.
16 citations,
June 2015 in “Seminars in Cutaneous Medicine and Surgery” Hair loss in people with darker skin has unique challenges and requires careful diagnosis and treatment.
15 citations,
September 1984 in “Veterinary Clinics of North America: Small Animal Practice” The document explains various skin conditions in cats and how to diagnose and treat them.
15 citations,
February 2021 in “Frontiers in immunology” Leptin, a hormone from fat cells, affects immune responses and can influence skin diseases and hair growth.
14 citations,
January 2008 in “Dermatology” Vitamin D made by the skin plays a role in immune defense and skin health, and more research is needed to understand its full effects.
12 citations,
November 2014 in “Journal of Cutaneous Medicine and Surgery” Antiviral medication valganciclovir may improve skin and hair in Trichodysplasia Spinulosa patients.
11 citations,
April 2016 in “The American Journal of Dermatopathology” Special and immunohistochemical stains are not routinely needed for diagnosing hair disorders.
8 citations,
February 2022 in “Vascular Health and Risk Management” Some skin conditions may increase the risk of heart disease, and understanding their connection could lead to better treatments.
8 citations,
June 2018 in “Primary Care: Clinics in Office Practice” Doctors should use a detailed patient history and physical exam to diagnose joint pain, and consult a rheumatologist early for suspected autoimmune diseases.
8 citations,
July 2016 in “Journal of Cutaneous Pathology” Two women were diagnosed with a rare melanoma that looked like hair loss but was actually a type of skin cancer.
7 citations,
July 2019 in “Clinics in Dermatology” Hair loss can indicate or worsen with systemic diseases, and treating the underlying condition is important.
7 citations,
January 2015 in “Current problems in dermatology” Hair loss can be caused by stress, infections, drugs, and various diseases, with treatment depending on accurate diagnosis.
6 citations,
March 2023 in “Journal of Ethnopharmacology” The study demonstrates that the Jieduquyuziyin prescription (JP), a traditional Chinese medicine, effectively alleviates systemic lupus erythematosus (SLE) complicated by atherosclerosis in ApoE-/- mice. JP reduced hair loss, stabilized body weight, and alleviated kidney damage, while also decreasing urinary protein, autoantibodies, and inflammatory factors. It inhibited aortic plaque deposition, stimulated lipid metabolism, and increased the expression of genes regulating cholesterol efflux (ABCA1, ABCG1, SR-BI, PPAR-γ). Additionally, JP suppressed the TLR9/MyD88/NF-kB signaling pathway, reducing inflammation and foam cell formation in macrophages. These findings suggest JP's potential therapeutic role in treating SLE with atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory pathways.
5 citations,
January 2012 in “PubMed” Anti-MND antibodies are present in various diseases, not just PBC, and their levels don't correlate with disease activity or skin symptoms.
4 citations,
January 2012 in “Chemical Immunology” Some drugs, especially biologics, can cause skin reactions that look like other skin diseases, and stopping the drug usually helps clear up these reactions.
4 citations,
July 2001 in “Journal of Cutaneous Medicine and Surgery” Tacrolimus is an effective treatment for several skin conditions with fewer side effects than cyclosporine.
2 citations,
January 2021 in “Przegląd Dermatologiczny (1959)” The article discusses various treatments for different types of non-scarring hair loss.
2 citations,
May 2016 in “Clínica e Investigación en Arteriosclerosis” Some skin conditions may increase the risk of heart disease, but are not yet included in cardiovascular prevention guidelines.
2 citations,
May 2020 in “JAAD case reports” Ruxolitinib can cause a delayed skin reaction on the nose.
2 citations,
January 2019 The document concludes that autoimmune skin disorders are treated with corticosteroids and immunosuppressive drugs.
2 citations,
March 2011 in “Journal of Cutaneous Pathology” The document suggests simplifying alopecia diagnosis and improving techniques for better accuracy.
1 citations,
October 2022 in “Rheumatology” Juvenile RHUPUS syndrome, a rare overlap of rheumatoid arthritis and systemic lupus erythematosus (SLE) in children, is underdiagnosed and not well understood. This case report describes an 11-year-old girl with polyarthritis deformans, profound asthenia, recurrent oral aphtosis, and massive hair loss. Diagnostic criteria for SLE and juvenile idiopathic arthritis (JIA) were met, with positive rheumatoid factor (RF), antinuclear antibodies (ANA), and anti-Sm antibodies. She was treated with methotrexate and hydroxychloroquine. The case highlights the importance of considering RHUPUS in pediatric patients with deforming arthropathy, despite its rarity.
1 citations,
June 2021 in “Journal of dermatology and dermatitis” Tyrosine kinase inhibitors show promise in treating some skin diseases but their definitive role in dermatology is still unclear.
1 citations,
January 1967 in “The BMJ” The document concludes that while some hair and scalp disorders can be treated, hair loss from destroyed follicles is permanent, and damaged hair can only regrow naturally.
1 citations,
October 2023 in “British journal of dermatology/British journal of dermatology, Supplement” In Germany, alopecia areata is common and often occurs with skin conditions like eczema and psoriasis, affecting women slightly more and varying by region.
1 citations,
March 2022 in “Dermatology Reports” Most hair disorder patients at the clinic were young adult males, with alopecia areata being the most common condition.
1 citations,
July 2020 in “Journal of cosmetic dermatology” A woman on immunosuppressants developed two rare scalp conditions, which improved with specific treatments.
1 citations,
May 2020 in “Journal of The American Academy of Dermatology” The authors agree more research with proper control groups is needed to understand hair loss.
1 citations,
January 2014 in “Health Renaissance” Pseudopelade of Brocq is hard to diagnose and treat, with limited effective options.