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Cyclosporin doesn't stop hair loss.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.

Caffeine in cosmetics may reduce cellulite, protect skin, and stimulate hair growth, but more research is needed on its use and effects.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

Eating 500 fewer calories a day and making lifestyle changes can improve PCOS symptoms and reduce diabetes risk; more research is needed on its causes and treatments.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

Myo-inositol helps improve skin conditions and metabolic profiles in young women with PCOS.

There is no clear recommendation for using selenium in cancer patients; it may be beneficial to correct low selenium levels before treatment.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Apoptosis is crucial for healthy skin and treating skin diseases.