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    Glossary Lipid Signaling

    lipids act as messengers to regulate cellular functions

    Lipid signaling refers to the process by which lipids (fat molecules) act as signaling molecules to regulate various cellular functions. These lipids can bind to specific receptors on cell surfaces or within cells, triggering a cascade of biochemical reactions that influence processes such as inflammation, cell growth, and metabolism. This mechanism is crucial for maintaining cellular homeostasis and responding to external stimuli.

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    1. Lipid‐mediated signalling and melanocyte function Pigment Cell & Melanoma Research · 2009 · 6 citations
    2. Lipid signaling in keratinocytes: Lipin-1 plays a PArt Journal of lipid research · 2016 · 1 citations
    3. Structural & functional studies of L-PGDS and SMPDL3A enzymes in lipid signaling family 2019
    4. Altered hair root gene expression profiles highlight calcium signaling and lipid metabolism pathways to be associated with curly hair initiation and maintenance in Mangalitza pigs Frontiers in Genetics · 2023
    5. Xiaozhi Yufa decoction ameliorates androgenetic alopecia through inhibition of MAPK signaling and regulation of lipid metabolism Frontiers in Pharmacology · 2025
    6. Adiponectin Signaling Regulates Lipid Production in Human Sebocytes PLoS ONE · 2017 · 32 citations
    7. Lipid signalling in plant responses to abiotic stress Plant Cell & Environment · 2015 · 646 citations
    8. The role of lipids in promoting hair growth through HIF-1 signaling pathway Scientific Reports · 2025
    9. The role of lipids in promoting hair growth through HIF-1 signaling pathway Research Square (Research Square) · 2024
    10. 447 Skin-Associated Cartilage Consists of Lipid-Filled Cells That Modify Hair Growth via BMP and WNT Signaling Journal of Investigative Dermatology · 2025
    11. Author response: The signaling lipid sphingosine 1-phosphate regulates mechanical pain 2018 · 1 citations
    12. Decision letter: The signaling lipid sphingosine 1-phosphate regulates mechanical pain 2017
    13. Integrated Multi-Omics Analysis Reveals Dysregulated Lipid Metabolism as a Novel Mechanism in Androgenetic Alopecia Biomedicines · 2026
    14. 613 Bacteria induce skin regeneration via IL-1β signaling Journal of Investigative Dermatology · 2021
    15. Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity Stem cells · 2018 · 24 citations
    16. Effective amelioration of hepatic inflammation and insulin response in high fat diet-fed rats via regulating AKT/mTOR signaling: Role of Lepidium sativum seed extracts Journal of ethnopharmacology · 2020 · 14 citations
    17. Exosomes Derived From Human Adipose-Derived Stem Cells Inhibit Lipogenesis Involving Hedgehog Signaling Pathway Frontiers in Bioengineering and Biotechnology · 2021 · 13 citations
    18. Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases International Journal of Molecular Sciences · 2022 · 6 citations
    19. 0952 Spatial transcriptomics reveal compartmentalized dysregulation of lipid metabolism in acne vulgaris Journal of Investigative Dermatology · 2025
    20. Integrative Proteo‐Transcriptomic Characterization of Androgenetic Alopecia Identifying ME1‐Mediated PPAR Signaling as a Potential Mediator Journal of Cosmetic Dermatology · 2024
    21. Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the Wnt/β-catenin signaling pathway Journal of ethnopharmacology · 2024
    22. 1317 Nicotinic acid suppresses sebaceous lipid synthesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA2) Journal of Investigative Dermatology · 2018
    23. 878 Influence of bovine milk oligosaccharides on sebocyte lipid content and inflammatory mediators Journal of Investigative Dermatology · 2017
    24. PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology Experimental Dermatology · 2019 · 24 citations
    25. 090 Reactive lipids from the secretome of senescent fibroblasts modify the extracellular matrix with functional consequences for resident cells Journal of Investigative Dermatology · 2024
    26. Hair Growth Cycle Is Arrested in SCD1 Deficiency by Impaired Wnt3a-Palmitoleoylation and Retrieved by the Artificial Lipid Barrier Journal of Investigative Dermatology · 2017 · 23 citations
    27. Expression of lipid-protein gene PLP2 in Liaoning cashmere goat Animal biotechnology · 2019 · 3 citations
    28. Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes Journal of Investigative Dermatology Symposium Proceedings · 2017 · 9 citations
    29. Protective role of agomelatine via modulation of TLR4/NF-κB: NLRP3/IL-1β signaling pathways in testosterone-induced benign prostatic hyperplasia in rats Naunyn-Schmiedeberg s Archives of Pharmacology · 2025
    30. Polyphenols rich Hibiscus rosa sinensis Linn. petals modulate diabetic stress signalling pathways in streptozotocin-induced experimental diabetic rats Journal of Functional Foods · 2015 · 11 citations