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17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

Hormone therapies like birth control pills and spironolactone are safe and effective for treating women's adult acne.

Some common medications can harm male fertility, but many effects can be reversed.

Clascoterone is safe for the heart, even at high doses.

Hormonal therapy is a good option for women with severe acne, especially when there's a chance of hormone imbalance.

Testosterone replacement may help post-menopausal women with androgen insufficiency, but more research is needed on its benefits and risks.

Over 50% of women over 50 experience hair loss, with minoxidil being the only proven effective treatment.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Minoxidil-loaded hyaluronic acid microneedles can effectively increase hair growth and could be a promising treatment for hair loss.

There are many treatments for common hair loss, but more trials are needed to decide which are best.

The conclusion is that obesity should be managed with a slow, balanced approach to diet and exercise, with medication and surgery as additional options, and education and access to care are important.

Some skin medications can have harmful interactions with the COVID-19 drug nirmatrelvir-ritonavir, but not with molnupiravir.

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

Possible new treatments for common hair loss include drugs, stem cells, and improved transplants.

The new gel for psoriasis is effective, stable, and easy to apply.

Ayurvedic treatments can help manage PCOS symptoms.

Prostate cancer prevention includes diet changes, supplements, and medications, with more answers expected soon.

The document advises health care providers on how to support transgender and gender-diverse youth with appropriate care and referrals.

Prostate cancer patients need early psychological and sexual support during radiotherapy to improve their quality of life.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Surgeons must understand the full care process for gender confirmation surgery to help transgender individuals effectively.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

The document concludes that low-dose oral contraceptives and hormonal therapies can manage perimenopause symptoms and reduce some health risks, but lifestyle changes and disease screening are also important.

Kimchi probiotics slightly improved hair density, but more research needed.

New treatments for hair loss should target eight main causes and use specific plant compounds and peptides for better results.

Liposomes improve the delivery and effectiveness of cosmetic ingredients but face challenges like cost and stability.

Stem cell therapies could be a promising alternative for hair loss treatment, but more research is needed to understand their full potential and safety.

Most men using teledermatology for hair loss treatment saw improved hair and self-esteem, with some experiencing side effects.

Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.