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    Glossary Letrozole

    medication that inhibits estrogen production to treat breast cancer

    Letrozole, also known by the brand name Femara, is a medication primarily used to treat breast cancer in postmenopausal women. It works by inhibiting the enzyme aromatase, which decreases the production of estrogen, a hormone that can promote the growth of certain types of breast cancer. Additionally, letrozole is sometimes used off-label to treat conditions like polycystic ovary syndrome (PCOS) and to stimulate ovulation in women facing infertility issues.

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    Research 30 of 377

    1. Combinatorial Therapy of Letrozole- and Quercetin-Loaded Spanlastics for Enhanced Cytotoxicity against MCF-7 Breast Cancer Cells Pharmaceutics · 2022 · 39 citations
    2. Alopecia in a premenopausal breast cancer woman treated with letrozole and triptorelin Annals of Oncology · 2003 · 15 citations
    3. Reduced estradiol synthesis by letrozole, an aromatase inhibitor, is protective against development of pentylenetetrazole-induced kindling in mice Neurochemistry International · 2015 · 14 citations
    4. Aromatase inhibition by letrozole attenuates kainic acid-induced seizures but not neurotoxicity in mice Epilepsy research · 2018 · 11 citations
    5. Clomiphene Citrate versus Letrozole for Ovulation Induction in PCOS: A Comparative Study Journal of South Asian Federation of Obstetrics and Gynaecology · 2018 · 3 citations
    6. Effect of palbociclib plus letrozole on patient-reported health-related quality of life: extended follow-up of the PALOMA-2 trial ESMO Open · 2025 · 2 citations
    7. Agaricus Subrufescens ameliorates ovarian dysfunction and regulates altered biochemical parameters in rats with Letrozole induced polycystic ovarian syndrome Journal of ovarian research · 2023 · 1 citations
    8. Protective Effect of “ <i>Ark‐e‐Kasni</i> ,” a Unani Formulation, in Letrozole and High‐Fat Diet–Induced Polycystic Ovarian Syndrome in Rats Journal of obstetrics and gynaecology research · 2026
    9. Letrozole-Assisted Ovulation Induction Combined with Lifestyle Modification in Women with PCOS: A Review Journal of Education Health and Sport · 2026
    10. Agaricus Subrufescens Ameliorates Ovarian Dysfunction and Regulates Altered Biochemical Parameters in Rats with Letrozole Induced Polycystic Ovarian Syndrome Research Square (Research Square) · 2023
    11. Efficacy of Letrozole (LE) Combined with Cabergoline (CE) in Comparison to LE alone in ovulation induction among patients with Polycystic Ovarian Syndrome (PCOS) and Hyperprolactinemia (HP) 2020
    12. Liarozole—a novel treatment approach for advanced prostate cancer: results of a large randomized trial versus cyproterone acetate Urology · 1998 · 52 citations
    13. Epidemiology, diagnosis, and management of polycystic ovary syndrome Clinical epidemiology · 2013 · 951 citations
    14. Evidence-Based and Potential Benefits of Metformin in the Polycystic Ovary Syndrome: A Comprehensive Review Endocrine Reviews · 2008 · 343 citations
    15. Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol Neuroscience · 2004 · 136 citations
    16. Health and fertility in World Health Organization group 2 anovulatory women Human Reproduction Update · 2012 · 88 citations
    17. Polycystic Ovary Syndrome Nursing Clinics of North America · 2018 · 87 citations
    18. Androgens and ovarian function: translation from basic discovery research to clinical impact Journal of Endocrinology · 2019 · 55 citations
    19. Pharmacotherapy of polycystic ovary syndrome - an update Fundamental & Clinical Pharmacology · 2011 · 34 citations
    20. Sex hormones modulate pathogenic processes in experimental traumatic brain injury Journal of neurochemistry · 2019 · 32 citations
    21. Contemporary medical therapy for polycystic ovary syndrome International journal of gynaecology and obstetrics · 2006 · 31 citations
    22. Synaptic Long-Term Potentiation and Depression in the Rat Medial Vestibular Nuclei Depend on Neural Activation of Estrogenic and Androgenic Signals PLoS ONE · 2013 · 25 citations
    23. Emerging concepts about prenatal genesis, aberrant metabolism and treatment paradigms in polycystic ovary syndrome Endocrine · 2012 · 25 citations
    24. Serum Androgen Bioactivity in Adolescence: A Longitudinal Study of Boys with Constitutional Delay of Puberty The Journal of Clinical Endocrinology & Metabolism · 2004 · 19 citations
    25. Endocrine and Reproductive Effects of Polycystic Ovarian Syndrome Obstetrics and Gynecology Clinics of North America · 2014 · 18 citations
    26. The Utility of Metformin Therapy in Reproductive-Aged Women with Polycystic Ovary Syndrome (PCOS) Current Pharmaceutical Biotechnology · 2014 · 18 citations
    27. Therapeutic options in the polycystic ovary syndrome Journal of Obstetrics and Gynaecology · 2007 · 16 citations
    28. Morpho‐regulation in diverse chicken feather formation: Integrating branching modules and sex hormone‐dependent morpho‐regulatory modules Development, Growth & Differentiation · 2018 · 13 citations
    29. Update on the therapeutic role of metformin in the management of polycystic ovary syndrome: Effects on pathophysiologic process and fertility outcomes Women s Health · 2025 · 12 citations
    30. Different synaptic stimulation patterns influence the local androgenic and estrogenic neurosteroid availability triggering hippocampal synaptic plasticity in the male rat 2017 · 10 citations