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Many patients with cutaneous lupus erythematosus experience hair loss and nail problems, which are important for diagnosis and treatment.

The document summarizes medical findings on topics like heart rhythm treatment, sleep apnea therapy, and various health conditions and treatments.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Restoring mitochondrial function in mice reversed their skin wrinkling and hair loss.

Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.

Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

High afamin levels are linked to metabolic syndrome and may predict its development in women with insulin resistance.

Nonclassic congenital adrenal hyperplasia is a genetic disorder causing hormone imbalances, affecting fertility and requiring personalized treatment.

Women with PCOS have unhealthy changes in their cholesterol particles that are not related to their body weight.

Leptin helps start the growth phase of hair.

Lower lipin 1β in belly fat is linked to insulin resistance in people with polycystic ovary syndrome.

Women with PCOS have higher levels of a certain growth factor, which can be reduced by taking metformin.

Selective Androgen Receptor Modulators (SARMs) are drugs that can control the effects of androgens in different tissues, potentially having fewer side effects and promising for treating various conditions.

Metformin helps improve symptoms and reproductive outcomes in people with polycystic ovary syndrome.

Honokiol might help reduce male skin aging by maintaining testosterone levels.

Some supplements may help with hair loss, but there's not enough strong evidence to recommend them without doctor advice.

The GH-IGF-I axis is likely involved in the hormonal imbalances seen in non-obese women with functional hyperandrogenism.

Finasteride's sexual side effects not caused by androgen deficiency or SRD5A inhibition.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.

Hair loss increases with age; alcohol raises risk, more female partners lowers it.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Women with epilepsy should be monitored for reproductive issues, which can be caused by epilepsy or its treatments, especially when using valproate.

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.