February 2026 in “Pharmaceuticals” This study introduced the KRDQN predictive framework, which outperformed existing methods in predicting adverse drug reactions and provided interpretable insights into drug mechanisms, aiding pharmacovigilance and clinical decision-making.
August 2023 in “International journal of research in Ayurveda and pharmacy” This review discusses the potential role of Garudan kizhangu ennai, a polyherbal Siddha formulation, in managing alopecia areata and highlights its various pharmacological properties, although further clinical studies are needed to confirm its efficacy.
44 citations
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August 1990 in “PubMed” This study provides evidence for K1 and K10 derivatives' presence in the inner root sheath and hair cuticle, suggesting that these hair follicle parts may follow familiar keratinization principles.
January 2013 in “Heilongjiang xumu shouyi” This study successfully cloned the KAP6.1 gene from Xinjiang fine-wool sheep and found its genetic sequence has high homology with sheep and goat sequences, indicating close genetic relationships.
April 2023 in “Journal of Investigative Dermatology” This study found that KROX20 is crucial for hair follicle development and epidermal homeostasis, as its deletion in skin epithelial cells led to hair loss and increased epidermal thickness.
133 citations
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June 1993 in “Molecular and Cellular Biology” This study found that a truncated region of the K5 promoter directs expression in stratified epithelia, particularly in epidermis, hair follicles, and tongue, potentially involving specific keratinocyte nuclear proteins in regulation.
75 citations
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October 1999 in “Differentiation” This study suggests that mouse keratin 6 isoforms, K6a and K6b, have overlapping but distinct expression profiles, differing notably in their expression in suprabasal cells and response to phorbol esters.
August 2025 in “International Ayurvedic Medical Journal” The authors concluded that, in this case study, Dhatri Lauha, Brahma Rasayana, and Asthiposhaka Vati effectively managed hair fall without adverse reactions.
2 citations
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August 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This review discusses the genetic origins of autosomal recessive woolly hair with hypotrichosis and reports no clinical results; it highlights the link to homozygous variants in the K25 keratin gene.
February 2025 in “International Journal of Advanced Research” This study highlights Ayurveda's holistic approach to managing hair loss, known as Khalitya, through lifestyle changes, purification therapies, and targeted medications, addressing the condition's association with modern sedentary lifestyles and poor dietary habits.
92 citations
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January 2012 in “International Journal of Biological Sciences” This article proposes an updated naming system for keratin-associated proteins and genes, aiming to improve data storage and retrieval by including species information and genetic variation.
January 2021 in “Skin Appendage Disorders”
January 2020 in “Indian Journal of Pharmaceutical Sciences” In this study, combining Kuntai capsules with nilestriol tablets for three months was found to reduce symptoms of perimenopausal syndrome and improve reproductive hormone levels more effectively than nilestriol alone; however, the benefits did not persist significantly beyond three months.
June 2017 in “Journal of Traditional and Folk Practices” This study enumerates the traditional uses of Begonia malabarica by tribes in Tamil Nadu, where it is reported to be used for treating a variety of ailments, with further research planned to evaluate its biological potential.
2 citations
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March 2012 in “Hiroshima University Acedemic Information Repository (Hiroshima University)” This article discusses the emergence of "Kainar syndrome" among residents near a nuclear test site in Kazakhstan and names brucellosis combined with vitamin deficiency as the suspected cause, without attributing it to nuclear tests.
79 citations
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October 1998 in “Genomics” This study found that the mK6alpha and mK6beta genes in mice are regulated differently at the mRNA level, with implications for understanding K6 gene evolution and function in mammals.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This single observational study reported that a combination of a morning Detox Drink regimen and Malasana yoga practice improved symptoms of chronic constipation in a 37-year-old woman over seven days.
June 2023 in “International journal of research in Ayurveda and pharmacy” In this case report, a 19-year-old female with hair fall and thinning identified as Khalitya in Ayurveda showed significant improvement in hair growth and shine after applying Malatyadi tailam, an Ayurvedic herbal oil blend, and following general hair care recommendations.
3 citations
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September 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that enhanced wound healing in oral mucosa involves a SOX2-regulated transcriptional network which includes increased expression of keratin K75, and interaction of K75 with the LINC complex may play a crucial role in promoting rapid wound repair.
13 citations
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March 1997 in “Research in Veterinary Science/Research in veterinary science” This study found that epithelial keratin K 6 is associated with hyperkeratotic and ulcerated changes in the gastric pars oesophagea of pigs, suggesting epithelial proliferation plays a role in ulcer development.
4 citations
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May 2014 in “International Journal of Research in Ayurveda and Pharmacy” This study documented the traditional medicinal uses of 60 plant species in Kolli Hills, India, highlighting their importance in the healthcare of the local tribal community.
5 citations
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June 2008 in “British Journal of Dermatology” 15 citations
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January 1991 in “Mammalian Genome”
June 2025 in “Indian Journal of Veterinary Medicine” In this case report, a persistent skin infection in a Bullykutta dog was resolved with a 10-day treatment regimen of Sulphamethoxazole, trimethoprim, omega fatty acids, and topical therapy after previous treatments failed.
6 citations
,
February 2023 in “Genes” This study found that overexpression of the CUX1 protein promotes proliferation of Hu sheep dermal papilla cells and affects key genes in the Wnt/β-catenin signaling pathway.
5 citations
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January 2016 in “BLDE University Journal of Health Sciences” This study observed that Kasisa Bhasma is safer and less toxic than Shodhita Kasisa, particularly at higher doses, when administered to experimental rats.
2 citations
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March 2023 in “BMC ecology and evolution” This study suggests that some keratin-associated proteins with antecedents found in non-haired animals may have roles beyond hair characteristics, possibly contributing to the evolution of hair follicles.
March 2010 in “European Journal of Cancer Supplements”
4 citations
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December 2017 in “International journal of research in ayurveda and pharmacy” This review discusses the traditional and pharmacological uses of Cuscuta reflexa, but it reports no new clinical results, calling attention to its potential antihypertensive, antidiabetic, and antioxidant properties.
86 citations
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May 2002 in “Journal of Investigative Dermatology” This study characterized a new human keratin, hK6irs1, specifically found in the inner root sheath of hair follicles, which suggests its role in the structural integrity and guidance of growing hair shafts.