11 citations
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October 2018 in “The Journal of Dermatology” This study suggests that decorin may help maintain hair follicle stem cells and its reduced expression could contribute to age-related hair loss.
9 citations
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August 2013 in “Archives of Dermatological Research” This study concluded that the expression of clock genes, specifically BMAL1, in hair follicles is linked to circadian rhythm, and BMAL1 regulates hair growth.
7 citations
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January 2016 in “Laboratory Investigation” TR3 is mainly found in hair follicle stem cells and may be involved in hair loss.
5 citations
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October 2016 in “Experimental Dermatology” This study found that activin A signaling is crucial for hair follicle neogenesis in human dermal papilla 3D cultures combined with mouse epidermal cells.
4 citations
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October 2021 in “Scientific Reports” This study found that NKIRAS2 expression affects skin tumor suppression and HRAS-driven transformation in mice, indicating its role in carcinogenesis depends on expression level and cellular context.
4 citations
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April 2015 in “Experimental Dermatology” This study found that OVOL1-regulated genes, particularly Fst and SFRP1, significantly affect the hair-inducing capacity of neonatal mouse dermal cells.
2 citations
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November 2022 in “Animal Bioscience” This study found that m6A-circRNA-ZNF638 enhances the activation of secondary hair follicle stem cells in cashmere goats by interacting with the miR-361-5p/Wnt5a pathway.
1 citations
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January 2023 in “Burns and trauma” This study found that tdDPC-EVs significantly improved wound healing by enhancing angiogenesis through the KLF4/VEGFA axis, offering advantages over traditional DPC-EVs.
1 citations
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January 2013 in “Journal of Investigative Dermatology” The document concludes that stem cells and their environments are crucial for skin and hair health and have potential for medical treatments.
May 2025 in “Cellular Oncology” This study suggests that dual inhibition of P-cadherin and c-Met could be an effective treatment strategy for head and neck squamous cell carcinoma by targeting resistant tumor cells.
January 2023 in “European journal of gynaecological oncology” This study found that depletion of KRT17 in endometrial cancer reduced cell growth, motility, and angiogenesis, suggesting KRT17 as a potential therapeutic target.
June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This pilot study suggests that a new preparation of platelet-rich plasma gel may improve symptoms and tissue regeneration in patients with en coup de sabre scleroderma, though further trials are needed to clarify its role.
August 2019 in “Journal of Invertebrate Pathology” This study observed that different alkaline buffers had a significant impact on the volume of liquid consumed by fall armyworm larvae, emphasizing the importance of measuring imbibed volumes to reduce dose errors in bioassays.
April 2019 in “Journal of Investigative Dermatology” This study suggests that dietary grape powder may reduce the severity of atopic dermatitis in a mouse model, highlighting its potential in both prevention and intervention settings.
April 2019 in “Journal of Investigative Dermatology” This study found that bioelectric and biochemical signaling mechanisms coordinate collective cell movement during chicken feather bud morphogenesis, suggesting a potential new angle for research in skin development and wound healing.
April 2019 in “Journal of Investigative Dermatology” This study suggests that hormone replacement therapy and oral contraception may have a protective role in scarring alopecia, as these were reported less frequently by patients with the condition compared to those with female pattern hair loss.
April 2017 in “Journal of Investigative Dermatology” This study found that the PON1 192 R allele was associated with an increased risk of psoriasis and altered lipid profiles in patients from Western Mexico.
April 2017 in “Journal of Investigative Dermatology” This study suggests that PKCß plays a critical role in modulating the dermal inflammatory microenvironment in response to dietary lipids in mice.
April 2017 in “Journal of Investigative Dermatology” This study demonstrates that genome-edited epidermal stem cells can continuously monitor blood glucose levels in vivo and potentially aid in diabetes treatment through skin somatic gene therapy.
April 2017 in “Journal of Investigative Dermatology” This study identified that dominant mutations in the KLHL24 gene cause epidermolysis bullosa through dysregulated autoubiquitination, leading to excessive degradation of keratin 14.
December 2016 in “University of Birmingham Institutional Research Archive (University of Birmingham)” This study suggests that the adrenal gland may contribute to prostate cancer treatment resistance and indicates potential steroid production or dependency in ovarian cancer.
September 2016 in “Journal of dermatological science” This study found that adult dermal papilla cells guided high-passage adult keratinocytes to produce new hair fibers, suggesting potential for large-scale hair follicle bioengineering.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that infiltrating M2 macrophages promote wound-induced hair neogenesis in mice by producing growth factors that activate the wnt signaling pathway during the late phase of wound healing.
January 2014 in “Journal of Investigative Dermatology” Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.
October 2013 in “Journal of Investigative Dermatology” Collagen VII helps skin heal and stay strong, sirolimus may lower skin cancer risk in kidney transplant patients, high-molecular-mass hyaluronan helps naked mole rats resist cancer, dermal γδ T cells aid in hair growth in rodents, and overexpression of IL-33 in mouse skin causes itchiness, offering a model for studying allergic inflammation treatments.
December 2012 in “Journal of Dermatological Science” In this study, estradiol was found to increase VEGF expression in cultured dermal papilla cells at physiological levels similar to pregnancy, suggesting that declining estrogen might contribute to female pattern hair loss in older Japanese women.
April 2017 in “Journal of Investigative Dermatology” This study identified altered neurological pathways and potential drug targets involved in androgenetic alopecia, suggesting areas for future research and possible therapies.
35 citations
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October 2017 in “Signal Transduction and Targeted Therapy” This study found that fibromodulin significantly reduces scar formation and boosts scar strength in rodent and porcine models, suggesting potential for FMOD-based therapies in cutaneous wound repair.
21 citations
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February 2017 in “PLoS ONE” This study found that RhoA influences embryonic stem cell proliferation through the PKN1-cyclin D1 pathway in vitro, suggesting RhoA as a potential target for wound healing therapies.
4 citations
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January 2021 in “Archives of dermatological research” This study developed a new human hair research model combining 3D spheroid dermal papilla fibroblasts with plucked anagen hair shafts, potentially improving the evaluation of hair follicle differentiation.