Dual Blockage of P-Cadherin and c-Met Synergistically Inhibits the Growth of Head and Neck Cancer

    May 2025 in “ Cellular Oncology ”
    Lihua Liu, Chan Oh, Mi Ae Lim, Sicong Zheng, Yudan Piao, Sang Hwa Ohm, Yujuan Shan, Shuyu Piao, Shan Shen, Young Il Kim, Ho-Ryun Won, Jae Won Chang, Mingyu Kim, Doh Hoon Kim, Ji Won Kim, Seung‐Nam Jung, Bon Seok Koo
    TLDR Blocking both P-cadherin and c-Met can effectively stop head and neck cancer growth.
    The study reveals that inhibiting P-cadherin leads to enhanced activation of c-Met/STAT3, which may contribute to the survival of resistant tumor cells in head and neck squamous cell carcinoma (HNSCC). The researchers propose that a dual inhibition strategy targeting both P-cadherin and c-Met could be an effective treatment approach for HNSCC, potentially overcoming resistance mechanisms and inhibiting tumor growth more effectively.
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