research Teriflunomide (Aubagio) for the Treatment of Multiple Sclerosis
Teriflunomide is an effective and generally safe oral treatment for relapsing MS, reducing relapses and slowing disability progression.
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research Madarosis: A Marker of Many Maladies
Losing eyelashes or eyebrows can be a sign of many different health problems and needs a careful approach to treat effectively.
research Oxygen, Metabolism, and Regeneration: Lessons from Mice
Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.
research Development of a Two-Dimensional Model for Predicting Transdermal Permeation with the Follicular Pathway: Demonstration with a Caffeine Study
Researchers developed a model that shows hair follicles increase skin absorption of caffeine by 20%.
research CD98hc (SLC3A2) Regulation of Skin Homeostasis Wanes With Age
CD98hc's role in skin health decreases with age.
research Two Hypomorphic Alleles of Mouse Ass1 as a New Animal Model of Citrullinemia Type I and Other Hyperammonemic Syndromes
Researchers created a new mouse model for studying Citrullinemia Type I and similar conditions, showing symptoms and treatment responses like those in humans.
research Skin and Hair: Models for Exploring Organ Regeneration
Skin and hair can help us understand organ regeneration, especially how certain stem cells might be used to form new organs.
research Zinc in Skin Pathology and Care
Zinc can help with some skin problems, but its effectiveness varies depending on the condition.
research Effects of PNU157706, a Dual 5α-Reductase Inhibitor, on Rat Epididymal Sperm Maturation and Fertility
PNU157706 reduced rat sperm movement and fertility without affecting offspring health.
research Glutamate Transporter SLC1A3 Mediates Inter-Niche Stem Cell Activation During Skin Growth
The protein SLC1A3 is important for activating skin stem cells and is necessary for normal hair and skin growth in mice.
research Inhibitory Activities of Puerariae Flos Against Testosterone 5α-Reductase and Its Hair Growth Promotion Activities
Puerariae Flos extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.
research Adult Epidermal Notch Activity Induces Dermal Accumulation of T Cells and Neural Crest Derivatives Through Upregulation of Jagged 1
Activating Notch in adult skin causes T cells and neural crest cells to gather, leading to skin issues.
research Straight Hair Associated with Interferon-Alpha Plus Ribavirin in Hepatitis C Infection
ALA-PDT is effective and safe for chronic X-ray dermatitis, providing complete or partial remission.
research Biphasic Effects of Minoxidil on the Proliferation and Differentiation of Normal Human Keratinocytes
Minoxidil affects cell growth in two ways: low doses increase growth, while high doses slow it down and can be toxic.
research Relative Influence of Ethanol and Propylene Glycol Cosolvents on Deposition of Minoxidil into the Skin
Ethanol over 50% helps minoxidil absorb better into skin.
research Azasteroids as Inhibitors of Testosterone 5α-Reductase in Mammalian Skin
Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.
research Cellular Senescence in Tissue Repair: Every Cloud Has a Silver Lining
Cell aging can be both good and bad for tissue repair.
research Solid Effervescent Formulations as a New Approach for Topical Minoxidil Delivery
Effervescent formulations may improve minoxidil delivery, increasing effectiveness and reducing applications needed.
research Evaluation of 5α-Reductase Inhibitory Activity of Certain Herbs Useful as Antiandrogens
Some herbs show promise as antiandrogenic agents.
research Profile of the Progesterone Derivative Chlormadinone Acetate: Pharmacodynamic Properties and Therapeutic Applications
Chlormadinone acetate is a strong, well-tolerated hormone used in birth control and hormone therapy with benefits for menstrual pain and skin conditions.
research Investigation of Drug Partition Property in Artificial Sebum
The conclusion is that measuring how drugs partition into artificial sebum is important for predicting their delivery into hair and sebaceous follicles, and it provides better information than traditional methods.
research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque
Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.
research Hair Follicle Targeting and Dermal Drug Delivery with Curcumin Drug Nanocrystals: Essential Influence of Excipients
Excipients greatly affect how well curcumin nanocrystals penetrate the skin and target hair follicles.
research Formulation and Optimization of Transfersome Containing Minoxidil and Caffeine
Minoxidil and caffeine in transfersomes improve hair growth treatment.
research In Vitro and In Vivo Skin Distribution of 5α-Reductase Inhibitors Loaded Into Liquid Crystalline Nanoparticles
Chitosan-coated nanoparticles improve skin delivery of hair loss treatments with fewer side effects.
research Fibromodulin Deficiency Alters Temporospatial Expression Patterns of Transforming Growth Factor-β Ligands and Receptors During Adult Mouse Skin Wound Healing
Mice lacking fibromodulin have disrupted healing patterns, leading to abnormal skin repair and scarring.
research Dutasteride Reduces Alcohol’s Sedative Effects in Men in a Human Laboratory Setting and Reduces Drinking in the Natural Environment
Dutasteride makes alcohol less sedating and may lead to less drinking in men.
research 1α,25-Dihydroxyvitamin D3 Modulates the Hair-Inductive Capacity of Dermal Papilla Cells: Therapeutic Potential for Hair Regeneration
Vitamin D3 can help improve hair growth by enhancing the function of specific skin cells and could be useful in hair regeneration treatments.
research Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation
Thymic transplantation normalized some T-cells but not others, maintaining immune function.
research The Development of Several Organs and Appendages Is Impaired in Mice Lacking Sp6
Mice without the Sp6 gene have problems developing several body parts, including hair, teeth, limbs, and lungs.