research Alopecia as a Systemic Disease
Hair loss can indicate or worsen with systemic diseases, and treating the underlying condition is important.
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research Cashmere Growth Control in Liaoning Cashmere Goat by Ovarian Carcinoma Immunoreactive Antigen-Like Protein 2 and Decorin Genes
OCIAD2 and DCN genes affect hair growth in goats by having opposite effects on a growth signaling pathway and inhibiting each other.
research Secretory Phospholipase A2-IIA Overexpressing Mice Exhibit Cyclic Alopecia Mediated Through Aberrant Hair Shaft Differentiation and Impaired Wound Healing Response
Mice with too much sPLA₂-IIA have hair loss and poor wound healing due to abnormal hair growth and stem cell depletion.
research Cutaneous Transcriptome Analysis in NIH Hairless Mice
Key genes linked to hair growth and cancer were identified in hairless mice.
research Efficacy of Superficial Cryotherapy on the Eyebrows of Patients With Alopecia Universalis Also Treated With Contact Immunotherapy on the Scalp: A Prospective, Split-Face Comparative Study
Superficial cryotherapy significantly improves eyebrow hair growth in alopecia universalis patients.
research Hair Follicle Morphogenesis and Epidermal Homeostasis in We/We Wal/Wal Mice with Postnatal Alopecia
The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.
research Two Mouse Mutations Mapped to Chromosome 11 with Differing Morphologies but Similar Progressive Inflammatory Alopecia
Two mouse mutations cause similar hair loss despite different skin changes.
research In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos
Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.
research Dermal EZH2 Orchestrates Dermal Differentiation and Epidermal Proliferation During Murine Skin Development
Dermal EZH2 controls skin cell development and hair growth in mice.
research Androgens Downregulate BMP2, Impairing the Inductive Role of Dermal Papilla Cells on Hair Follicle Stem Cells Differentiation
Androgens reduce BMP2, which weakens the ability of certain cells to help hair stem cells become different types of cells.
research Assessment of Markers Expressed in Human Hair Follicles According to Different Skin Regions
Different body parts have varying levels of certain hair follicle markers.
research Hairless Controls Hair Fate Decision via Wnt/β-Catenin Signaling
The Hairless gene is crucial for hair cell development, affecting whether skin cells become hair or skin and oil gland cells.
research Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche
The Foxn1(-/-) nude mouse shows disrupted and expanded skin stem cell areas due to high Lhx2 levels.
![Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia](/images/research/9620bd26-3366-4f2a-bcac-f511697bbc41/small/35997.jpg)
research Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia
A new compound shows promise as a topical treatment for hair loss.
research Analysis of the Expression Pattern of the Carrier Protein Transthyretin and Its Receptor Megalin in the Human Scalp Skin and Hair Follicles: Hair Cycle-Associated Changes
The proteins transthyretin and megalin are more present in the growth phase of hair, suggesting they might affect hair health and growth.
research Female-Patterned Alopecia in Teenage Brothers with Unusual Histologic Features
Two teenage brothers had a rare, treatment-resistant form of female-pattern hair loss with unusual scalp changes.
research Transforming Growth Factor-Alpha Immunoreactivity During Induced Hair Follicle Growth Cycles in Sheep and Ferrets
TGF-alpha is present in sheep and ferret skin and may affect hair growth without directly stimulating cell proliferation.
research Disorders of Hair
The document concludes that hair analysis is not good for assessing nutrition but can detect long-term heavy metal exposure.
research Differential Impact of Environmental Factors on Systemic and Localized Autoimmunity
Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.
research Engineered Skin Substitute Regenerates Skin with Hair Follicle Formation
The engineered skin substitute helped grow skin with hair on mice.
research Desmoplastic Trichoepithelioma: Histopathologic and Immunohistochemical Criteria for Differentiation of a Rare Benign Hair Follicle Tumor From Other Cutaneous Adnexal Tumors
The document concludes that recent studies help tell apart desmoplastic trichoepitheliomas from other skin tumors, but more research is needed for clear differentiation.
research Incipient Diabetes Mellitus and Nascent Thyroid Disease Presenting as Beard Alopecia Areata: Case Report and Treatment Review
Beard hair loss can signal early diabetes and thyroid issues, treatable with specific cream.
research Thiosulfate Promotes Hair Growth in Mouse Model
Thiosulfate may help hair grow faster in mice and works well with a common hair growth treatment.
research Dissociated Skin Cells Regenerate Hair Follicles in a Microwound: The Punch Assay
The "Punch Assay" can regenerate hair follicles efficiently in mice and has potential for human hair regeneration.
research In Vitro Identification of a Stem Cell Population from Canine Hair Follicle Bulge Region
Researchers found stem cells in dog hair follicles using specific markers.
research Rapid Preparation of a Noncultured Skin Cell Suspension That Promotes Wound Healing
Researchers developed a new method to quickly prepare skin cells that improve wound healing in rats.
research Differentiation of Nestin-Negative Human Hair Follicle Outer Root Sheath Cells Into Neurons In Vitro
Human hair follicle cells can be turned into neural stem cell-like cells, which might help treat brain diseases.
research Canonical and Non-Canonical Wnt Signaling Control the Regeneration of Amputated Rodent Vibrissae Follicles
Both main and alternative Wnt signaling are important for regrowing rodent whisker follicles.
research Epidermal Cells Expressing Putative Cell Markers in Nonglabrous Skin Near the Distal End of the Arrector Pili Muscle
Certain skin cells near the base of hair muscles may help renew and stabilize skin, possibly affecting skin disorder understanding.
research Noninflammatory, Nonpruritic Alopecia of Horses
Some horses lose hair without inflammation or itching due to various conditions, and while mainly a cosmetic issue, diagnosis requires examination and biopsies, and breeding is not advised if it's hereditary.