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This study found that the Bsk phenotype in mice did not result from a recombination event between specific keratin genes, leaving the gene linked to this mutation unidentified.

This study found that the absence of Sgk3 in mice leads to impaired hair follicle maturation, characterized by reduced cell proliferation, increased apoptosis, and premature regression.

This study developed a 3D skin model with immune and endothelial cells, which may enhance understanding of skin biology and diseases due to its closer approximation to native skin.

This source reviews the common skin-related side effects of tyrosine kinase inhibitors in treating endocrine cancers and emphasizes that proactive, multidisciplinary management can effectively control these adverse events without compromising cancer treatment efficacy.

Lasheras-Pérez et al. reported that JAK3 and TYK2 proteins are activated in certain forms of primary cicatricial alopecia, suggesting the JAK/TYK/STAT pathway as a potential therapeutic target for these conditions.

The LTF gene may help predict and manage nonspecific orbital inflammation.

This study reports that the monoclonal antibody BKN-1 specifically stained basal cell epithelioma cells and certain normal skin structures, indicating a similarity in keratin expression between the tumor and follicular epithelium below the isthmus portion.

This study demonstrates a sample preparation method for wool follicles that allows for clear keratin labeling and ultrastructural preservation in microscopy, reducing common artefacts from conventional fixation techniques.

This study reported that the novel AKT inhibitor CCT128930 demonstrated significant antitumor activity in human cancer cell lines and xenografts, highlighting its potential as an anticancer therapy.

In this open-label trial, tofacitinib showed dramatic clinical responses in most patients with moderate-to-severe alopecia areata, supporting further research into JAK inhibitors for this condition.

This review outlines the key principles and clinical applications of multimodal non-invasive skin imaging technologies, emphasizing their combined strengths in enhancing diagnosis and treatment assessment in dermatology.

This research found that the microtubule catastrophe factor KIF18B plays a crucial role in promoting spindle orientation in keratinocytes, linking this process to cell fate decisions during hair follicle morphogenesis.

The study reports that the AVET system showed higher efficiency in transfecting cultured human keratinocytes compared to SuperFect and PrimeFector, with AVET reaching levels of enzyme activity similar to normal cells in keratinocytes from lamellar ichthyosis patients.

This study developed a tissue-engineered model of innervated skin, allowing for examination of how epidermis and capillaries affect nerve growth and offering a tool for further research on skin-related processes.

This review highlights how intravital microscopy has advanced understanding of tissue homeostasis and cancer progression, focusing on how tumor cells exploit physiological processes for growth; it reports no new experimental findings.

In this study, Trichoscan®, reflectance confocal microscopy, and optical coherence tomography were found to be reliable noninvasive tools for measuring hair growth and follicle analysis after hair removal.

This study found that systemic treatment with DS77754007, a KLK5 inhibitor, improved skin symptoms in a mouse model of Netherton Syndrome more effectively than certain antibody treatments, suggesting KLK5 inhibition as a promising therapeutic approach for this condition.

This study found that enteroendocrine cells play a key role in coordinating stem cell migration towards wounds in the Drosophila intestinal epithelium, aiding tissue repair through non-canonical Wnt signaling.

This issue information abstract introduces a collection of articles, including one on hair keratins' unique filament formation, without reporting new experimental findings itself.

In this study, keratin‐based hydrogels incorporating calcium ions were developed to effectively deliver atorvastatin, showing potential for localized anti‐fibrotic therapy through controlled drug release and maintaining drug bioactivity in vitro, supported by thorough physicochemical and mechanical characterization.

This study found that oral JAK3 and TYK2/JAK1 inhibitors improved clinical outcomes in alopecia areata patients by reducing immune responses and enhancing hair keratin expression, with stronger effects in those with shorter disease duration.

Ritlecitinib reduces alopecia areata symptoms by blocking JAK3/TEC signaling and T-cell activity.

This research discusses the parallel clinical development of ritlecitinib, an oral Janus kinase 3/tyrosine kinase inhibitor, for treating conditions such as alopecia areata, vitiligo, ulcerative colitis, Crohn's disease, and rheumatoid arthritis. Results are not reported in the abstract.

This review summarized the latest knowledge suggesting that Janus kinase inhibitors may have therapeutic potential for treating skin diseases like atopic dermatitis and psoriasis, especially when conventional therapies do not work.

This study found that human hair keratin artificial tendons have low antigenity and may serve as an effective substitute for tendon repair in the upper extremities.

This study found that the ID2 gene was highly expressed in bulge-derived keratinocytes when exposed to contact sensitizers and may serve as a marker to distinguish sensitizers from irritants during in vitro testing.