JAK Family Expression And Therapeutic Implications In Primary Cicatricial Alopecias

    October 2025 in “ International Journal of Dermatology ”
    Juan Ruano
    Studysummary Lasheras-Pérez et al. reported that JAK3 and TYK2 proteins are activated in certain forms of primary cicatricial alopecia, suggesting the JAK/TYK/STAT pathway as a potential therapeutic target for these conditions.
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    Research cited in this study 2

    1. A Phase 2a Trial of Brepocitinib for Cicatricial Alopecia Journal of the American Academy of Dermatology · 2024
    2. Frontal Fibrosing Alopecia Shows Robust T Helper 1 and Janus Kinase 3 Skewing British journal of dermatology/British journal of dermatology, Supplement · 2020