This review supports iron deficiency anemia as a valid cause of chronic generalized pruritus and suggests potential mechanisms by which iron deficiency may lead to pruritus, but reports no new clinical results.
November 2018 in “Springer eBooks” Children need early diagnosis and treatment for iron-deficiency anemia to prevent learning problems and promote health.
March 2012 in “EFSA Journal” This analysis concluded that the evidence does not establish a cause-and-effect relationship between iron intake and the maintenance of normal hair growth in non-menopausal women with excessive hair loss.
5 citations
,
August 2003 in “British Journal of Dermatology” This article discusses the association between chronic diffuse telogen hair loss in women and iron deficiency, supporting the view that iron's role is unclear and often overstated, but reports no new clinical results.
26 citations
,
June 2020 in “Polymers” This study reported that a magneto-responsive transdermal microneedle system delivered Minoxidil effectively and significantly increased hair density by 800% in mice with androgenetic alopecia after 10 days.
7 citations
,
January 2016 in “Hair therapy & transplantation” This study reported significantly lower levels of serum iron, ferritin, and calcium in young patients with premature gray hair compared to controls, implying that supplementation might prevent further graying.
May 2026 in “AlQalam Journal of Medical and Applied Sciences” In this study, researchers found that relying solely on ferritin to assess iron status in young females with higher BMI may lead to inaccurate diagnoses of iron deficiency due to inflammation-related ferritin elevation.
53 citations
,
July 2014 in “American Journal of Physiology-Endocrinology and Metabolism” This study found that testosterone-enanthate increased red blood cell production and altered iron homeostasis in older hypogonadal men without being affected by finasteride, indicating these effects do not require type II 5α-reductase enzyme activity.
9 citations
,
January 2016 in “Case Reports in Medicine” This study reported two cases of ryzophagia among nonpregnant women in the US, with symptoms resolving after iron dextran therapy, suggesting a link with iron deficiency.
7 citations
,
February 2017 in “The American journal of medicine” This case report describes a 34-year-old woman who, after Roux-en-Y gastric bypass surgery, experienced improvements in symptoms of dizziness and energy following treatment with oral ferrous sulfate for iron deficiency.
4 citations
,
May 1989 in “Journal of the Royal Society of Medicine” Crohn's disease can cause hair loss before other symptoms appear.
3 citations
,
January 2017 in “Journal of Pakistan Association of Dermatology” This study found a significant association between low serum ferritin levels and nonscarring alopecia in women, suggesting the importance of addressing iron deficiency for treatment effectiveness.
1 citations
,
August 2023 in “Cutis” This review discusses the role of ferritin in iron homeostasis and its potential utility in diagnosing iron deficiency as a cause of hair loss, while noting that ferritin's impact on skin and hair disorders is not fully understood.
March 2026 in “International Journal of Clinical Dermatology” This study found that all 26 patients with specific skin lesions, primarily young females, were confirmed to have iron deficiency anemia after ruling out other possible causes such as zinc deficiency and pellagra, highlighting the importance of considering anemia as a diagnosis in such cases.
October 2023 in “Journal of Family Medicine and Primary Care” This survey in Riyadh Province found that most participants identified malnutrition as the leading cause of iron deficiency anemia and reported symptoms like weakness and cold extremities.
239 citations
,
July 2002 in “Clinical and Experimental Dermatology” This review explores the role of nutritional factors in hair loss, noting that iron and l-lysine supplementation may benefit some individuals, while excessive supplements can lead to hair shedding.
7 citations
,
January 2017 in “Journal of Clinical Biochemistry and Nutrition” This study found that vitamin D was positively associated with serum ferritin levels in Korean women without metabolic syndrome, but this association was not observed in those with metabolic syndrome.
March 2024 in “International journal of molecular sciences” This study suggests that abnormal levels of zinc, copper, and iron in serum or hair may serve as auxiliary and prognostic tests for various skin diseases, though further research is necessary due to conflicting data.
July 2019 in “Journal of The American Academy of Dermatology” This article discusses female pattern hair loss and concludes that the utility of lab markers for screening associated conditions remains unclear; no new clinical results are presented.
124 citations
,
August 1990 in “British Journal of Dermatology” Diffuse alopecia in women may be related to androgens and iron deficiency, and basic hormone and nutrient screening is useful.
9 citations
,
October 2010 in “Journal of the American Academy of Dermatology” Iron deficiency might cause hair loss, but better testing is needed.
180 citations
,
October 2019 in “British journal of haematology” These guidelines provide updated recommendations for healthcare professionals on preventing, diagnosing, and treating iron deficiency in pregnant and postpartum women in the UK, acknowledging the lack of high-quality evidence for many current practices.
2 citations
,
November 2022 in “Bioscience Reports” This review explores the similarities between polycystic ovary syndrome and hemochromatosis in terms of iron overload and suggests that addressing gut dysbiosis might help manage iron levels in these conditions.
This review highlights that iron deficiency is a significant yet often overlooked contributor to the development of immune-mediated inflammatory skin diseases, suggesting that iron dysregulation may drive inflammation and metabolic imbalances in conditions like psoriasis and atopic dermatitis.
This study developed a mathematical model using hair biomarkers (levels of Mg, K, Fe, Al, Cr) to noninvasively predict iron content in Hereford cattle muscle tissue, potentially improving livestock management and meat quality.
163 citations
,
November 2003 in “Journal of Investigative Dermatology” This study found that women with androgenetic alopecia or alopecia areata have significantly lower serum ferritin levels than those without hair loss, suggesting a potential link between these types of alopecia and decreased iron stores.
134 citations
,
December 2018 in “Dermatology and Therapy” This review discusses the potential role of vitamins and minerals in managing non-scarring alopecia but reports no clinical results; the authors advocate for further controlled trials to explore these relationships.
70 citations
,
June 2010 in “Clinics in Dermatology” This review discusses how changes in hair and skin may indicate underlying vitamin deficiencies and emphasizes the need to identify populations at risk for these deficiencies; it reports no new results.
67 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This review discusses telogen effluvium, a common type of hair loss, focusing on differentiation from other conditions and potential causes, but presents no new research findings.
64 citations
,
March 2021 in “Anaesthesia” This review discusses the history and impact of iron deficiency anemia in women, highlighting its prevalence and the need for better detection and care, especially for those undergoing anesthesia.