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Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

Androgens affect hair growth and shedding, with genetic and non-genetic factors influencing baldness.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Removing the VDR gene in skin cells reduces their growth and affects hair-related genes.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

The document concludes that more research is needed to fully understand the causes of PCOS.

Hair diversity is influenced by complex genetics and environmental factors, requiring more research for practical solutions.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

A certain smell receptor in hair follicles can affect hair growth when activated by a synthetic sandalwood scent.

Early treatment of PCOS in teens is crucial to prevent long-term health issues like diabetes and heart disease.

Early signs of PCOS in girls, like irregular periods and polycystic ovaries, suggest a need for early diagnosis and intervention to prevent further health issues.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Certain gene variations may protect against skin issues and oxidative stress in women with PCOS.

Vitamin D boosts a specific gene activity in kidney cells that could improve heart and kidney function.

GPR39 is linked to certain cells in the sebaceous gland and helps with skin healing.

Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.

Metformin works better for adolescent girls with PCOS who have certain genetic variations.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

A young patient with unusual insulin resistance and high testosterone levels had a rare INSR gene mutation.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

Human scalp hair follicles can produce hormones and have a system similar to a brain-body communication network.

Skin symptoms can indicate endocrine disorders and have various treatments.

PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.

Premature balding in some men may be linked to altered hormones, but it's not the male equivalent to polycystic ovary syndrome or metabolic syndrome.

PCOS in teens is hard to diagnose, linked to genetics and lifestyle, and managed with weight loss and medication.