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Metformin has limited effectiveness for improving PCOS symptoms and lacks clear benefits, needing more research to confirm its efficacy.

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

Melatonin improved mental health and metabolism in women with PCOS.

Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.

Quercetin may help with PCOS symptoms, but more research is needed.

Plant-based ingredients are effective and safe for modern skincare products.

Eating high glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

Ephrins slow down skin and hair follicle cell growth.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

The document concludes that treating PCOS requires a combination of drugs to manage reproductive and metabolic symptoms, with more research needed on combination therapies.

CD98hc's role in skin health decreases with age.

Two distinct pathways direct proteins to vacuoles in Arabidopsis, affecting root hair growth and protein targeting.

Metformin should be used for PCOS mainly in those with glucose intolerance, and has limited benefits for infertility or hirsutism.

Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.

Metformin improves menstrual cycles and hormone levels in women with PCOS, mostly within the first 6 months.

ROOT HAIR SPECIFIC 10 (RHS10) reduces the length of root hairs in Arabidopsis plants.

New treatments for PCOS focus on insulin resistance and reducing testosterone levels, along with traditional hormone therapies.

Acanthosis nigricans is a skin condition that may indicate a higher risk for insulin resistance and type 2 diabetes, and more research is needed to understand and treat it.

A team approach is crucial for managing PCOS, with dermatologists playing a key role.

Insulin resistance in women with PCOS can lead to serious health issues, but lifestyle changes and certain medications can help manage symptoms.

The study concluded that three enzymes are important for plant development by affecting sugar composition and calcium binding in plants.

Women with PCOS have higher levels of AMH in their blood and follicles, and this can help predict their risk of overreaction to fertility treatments.

Early onset baldness in men may indicate a condition similar to PCOS, linked to heart disease, diabetes, and prostate issues.

Removing vitamin D and calcium receptors in mice skin cells slows down skin wound healing.

Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.

Women with PCOS who had antiandrogenic treatment before pregnancy had fewer complications than those without treatment.

Genes linked to fibrosis are more active in people with central centrifugal cicatricial alopecia.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

Researchers found potential urine markers for polycystic ovary syndrome, including testosterone-glucuronide and 11α-hydroxyprogesterone, which may help diagnose the condition.

Stem cell differentiation is crucial for skin barrier maintenance and its disruption can lead to skin diseases.