Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, researchers identified a highly reactive, isozyme-specific sequence for TGase 3, contributing to understanding its distinct functional role and activity distribution in the mouse epidermis.

This study found that in a human skin organ culture model of pemphigus vulgaris, split formation led to significant upregulation of IFNγ and TNFα-related genes, indicating secondary effects from mechanical stress, not direct changes from autoantibodies.

This review highlights that alopecia areata is characterized by three immune endotypes, and while JAK inhibitors offer temporary control, upcoming multi-omics diagnostics and immune reprogramming strategies may achieve longer-lasting remission, according to this analysis.

This study evaluated 386 patients with inborn errors of immunity and found that over half exhibited cutaneous, ocular, or hair manifestations, with bacterial skin infections and eczema being particularly prevalent. These findings may aid early diagnosis, especially in pediatric cases.

This review discusses the significance of IL-1 family cytokines in skin inflammation and pathology, emphasizing their interactions with microbes and potential therapeutic applications, but reports no new clinical results.

This study identified a novel G207E STING mutation causing a distinct phenotype involving alopecia, photosensitivity, and thyroid dysfunction, and suggests that common polymorphisms in TMEM173 and IFIH1 may influence disease presentation.

This study found that D-peptide crosslinked MAP hydrogels accelerate skin regeneration and promote adaptive immunity, despite faster scaffold degradation in vivo.

Bullous pemphigoid can look like erythema multiforme, so awareness is needed for proper treatment.

This study found that in mice with alopecia areata, CD8+ T cells showed clonal expansion and specific regulatory networks, which might help identify new therapeutic targets for patients not responding to JAK inhibitors.

In this study, epidermal EGFR ablation in a mouse model led to significant local and systemic inflammatory responses, highlighting EGFR's role in maintaining skin immuno-homeostasis.

This study found that using particle-based antigen delivery in combination with cyanoacrylate skin surface stripping is an effective needle-free method for targeting HIV-1 p24 protein to skin cells, enhancing transcutaneous vaccination potential.

This study suggests that Merkel cell polyomavirus T antigen-positive cells resembling Merkel cell carcinoma may originate from epithelial cells in human hair follicles, potentially informing future transgenic mouse models for this cancer.

This study found that epithelial cells in the skin of live mice regulate the density and spatial organization of immune cells, which actively maintain their position despite constant cell turnover.

This study analyzed blood samples from individuals with alopecia areata and found that NKG2D+ immune cells, particularly memory-like NK cells, may better correlate with disease activity compared to CD8+ cells, though significant variability among individuals complicates these findings.

This case report describes a patient with primary cutaneous natural killer/T-cell lymphoma, nasal type, where monoclonal Epstein–Barr virus genome expansion was associated with terminal aggressive behavior after an indolent clinical course.

This study found that CD1a-restricted CD4+ T cells responsive to lysyl-phosphatidylglycerol were more frequent in the blood of atopic dermatitis patients, suggesting a potential role in the disease's Th2-mediated pathology.

This study suggests that contact sensitizers may treat alopecia areata by expanding suppressor cells and interfering with antigen presentation to lymphocytes.

This review explores the emerging roles of NK cells in various diseases, including allergies and skin conditions, and reports no new clinical results while indicating NK cell involvement in immune processes.

A heart transplant patient developed a skin condition called epidermodysplasia verruciformis after taking immune-suppressing drugs.

This study developed a 3D bioprinted skin model to mimic pemphigus vulgaris, providing a tool to study disease mechanisms and test targeted therapies by reproducing the architecture and pathogenic disruptions of native skin.

This study suggests that sweat glands may have an immune privilege similar to hair follicles, and disruptions in this could contribute to autoimmune skin diseases.

A bull with a gene mutation was asymptomatic, synthetic retinoids cause hair loss, and new therapeutic targets were identified for skin diseases.

In this study, researchers found that quiescent stem cells resist immune attack due to downregulated antigen presentation, which may help explain the immune evasion of early cancer-initiating cells.

This research suggests that hair follicle-derived cytokines IL-7 and IL-15 are crucial for maintaining resident memory T cells in the skin, which may be relevant for diseases like cutaneous T cell lymphoma.

This paper discusses the challenges of diagnosing drug eruptions, emphasizing the nonspecific patterns and unclear pathomechanisms, and calls for further research using new biologic drugs to understand these reactions better.

This study supports that an antibody response against anagen-specific hair follicle antigens, including trichohyalin and keratin 16, may play a role in alopecia areata.

Monocyte-derived dendritic cells play a key role in UVB-induced skin sensitivity and inflammation.

This study found that alopecia areata patients who responded poorly to topical immunotherapy had impaired peripheral blood mononuclear cell responses to T-cell stimulants.

This study concluded that combining cyanoacrylate skin surface stripping with particle-based antigen delivery effectively targets HIV-1 p24 protein to skin cells, supporting its potential for needle-free transcutaneous vaccination.