Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses the challenges of skin graft acceptance and examines current strategies and alternatives for full-thickness skin replacement and repair, noting that immunological rejection remains a significant hurdle.

This review discusses the role of immune privilege collapse in the pathogenesis of alopecia areata, emphasizing the potential for therapeutic manipulation of hair bulb immune privilege to offer new treatment options, and reports no new results.

This study suggests that finasteride's effect on promoting hair growth in men with androgenetic alopecia may be due to its inhibition of 5aR2 localized in hair follicles.

This study concluded that heterozygous NFKB2 mutations lead to a distinct and severe form of primary immunodeficiency with early onset, primarily T cell-mediated autoimmunity, and impaired B-cell differentiation.

This review examines the interaction between the extracellular matrix and immune cells in skin diseases and evaluates advanced therapies that target involved molecular mechanisms, reporting no new clinical findings.

This study found that inhibiting TGF-β receptors in adult dermal fibroblasts restored their function and increased resistance to Staphylococcus aureus infection by enhancing their adipogenic and antimicrobial capabilities.

This study found that nanoemulsions of different sizes vary in their ability to penetrate skin layers, with smaller sizes aiding transdermal delivery and potential applications in transcutaneous immunization.

This case series suggests a possible, though likely very rare, association between vaccinations and hair loss, calling for further research in more defined populations.

This study found that in healthy men, higher levels of free testosterone were associated with a stronger immune response to the influenza vaccine, suggesting androgens may function as immunomodulators rather than strict immunosuppressants.

This study describes and characterizes four cases of alopecia areata induced by immune checkpoint inhibitor therapy in cancer patients, highlighting the importance of recognizing and managing these hair-related adverse events.

This review update suggests that mycophenolate mofetil may increase complete disease remission in proliferative lupus nephritis compared to intravenous cyclophosphamide, but with low certainty of evidence.

This study observed that melanogenesis in human hair follicles is linked to anagen phases, with melanocyte activity and enzyme expression being region-specific to the nascent bulb.

In this study, AS101 combined with chemotherapy significantly reduced the severity of chemotherapy-induced alopecia in non-small-cell-lung-cancer patients and may involve immune mechanisms related to IL-1 and PGE2.

This study suggests that enhancing glycolysis in MSCs may improve their immune functions and therapeutic potential, although more evidence is needed to understand the direct metabolic mechanisms involved.

This review explores animal models of alopecia areata, particularly focusing on the insights they've provided into the disease's immune mechanisms and potential treatment approaches, without reporting new experimental data.

This study highlights that adverse effects from finasteride may persist in men after discontinuation, indicating a potential "post-finasteride syndrome.

This study found that combining low-dose spironolactone with metformin provided greater clinical benefits and improved treatment compliance in women with PCOS compared to either drug alone.

This study found that treating mtDNA mutator mice with the antioxidant SkQ1 delayed aging traits and extended their lifespan, potentially by alleviating mitochondrial dysfunction caused by reactive oxygen species.

Immunocompromised patients can develop skin and hair issues due to a virus.

This review examines histochemical and immunohistochemical markers to differentiate apocrine and eccrine sweat glands, highlighting their distinct markers, though it reports no new clinical findings.

This study observed that eliminating positional error in hair segment analysis can improve understanding of changes in isotopic composition, aiding the identification of pathological conditions and dietary patterns.

This study found that monoclonal antibodies identified distinct staining patterns in benign and malignant skin appendage tumors, highlighting their potential as markers for analyzing skin tumors.

This article reviews the role of microRNAs in skin-related conditions like psoriasis and wound healing and highlights their potential as therapeutic targets and diagnostic biomarkers, without reporting new experimental results.

This study found that biallelic mutations in the TTC7A gene affect lymphocyte and gut epithelial cell function, thereby contributing to the development of inflammatory bowel disease in patients.

This study found that thalidomide increased peripheral lymphocyte counts and reduced inflammation in lupus erythematosus patients, but was associated with polyneuropathy, suggesting careful use in refractory cases.

This case report describes an HIV-infected patient on HAART who developed autoimmune diseases, including alopecia universalis and Graves' disease, associated with immune restoration after CD4 cell count increases.

This study found that patients with alopecia areata had higher levels of Th17 cells and lower levels of regulatory T cells compared to healthy controls, suggesting an immune imbalance in these patients.

This review discusses the challenges and contradictions in understanding nanoparticle penetration and toxicity in human skin, emphasizing the need for standardized testing and further research on particles smaller than 10 nm.

This study concluded that sebaceous glands are the main pathway for the antiandrogen RU 58841 to permeate the skin, with liposomes enhancing localization in these glands.