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The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Aging causes skin stem cells to work less effectively.

Periodontal ligament stem cells show promise for regrowing tissues but require more research for safe, effective use.

Antibiotics can reduce acne but may lead to resistant bacteria, and understanding the skin's bacteria is important for treatment.

MicroRNA-302 helps improve the conversion of body cells into stem cells by blocking NR2F2.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Children with atopic dermatitis often have sleep problems, affecting their growth and behavior.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Recombinant cytokine therapy can cause skin reactions ranging from mild to severe.

Pure carbon nanotubes are safe for mice, but impure ones cause immune issues and hair loss.

COVID-19 can cause skin issues like rashes and "COVID toes," and people with skin conditions should adjust their treatments if they get the virus.

Nutraceuticals may improve skin health and protect against aging, but more research is needed on their optimal use and possible health risks.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

The document concludes that specific itchy skin diseases during pregnancy have varying fetal risks and treatments, including corticosteroids and other medications.

Methotrexate is a key, cost-effective drug for skin conditions, but requires careful monitoring for side effects.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Children with atopic dermatitis often have sleep problems due to itching and may benefit from melatonin, which helps with sleep and skin symptoms.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

Immunosuppressive and anti-TNF therapies in IBD patients can increase the risk of skin cancer and cause various skin issues.

Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.

Low level laser therapy works best for hair loss, followed by PRP, finasteride, and minoxidil.

Some skin conditions may indicate metabolic syndrome, which could help with early detection and management of related health issues.

Tofacitinib was effective in treating hair loss in two patients with alopecia universalis.

A boy with alopecia regrew hair using a vitamin D cream after other treatments failed.

People with atopic dermatitis are more likely to develop other skin conditions due to shared genetics and immune pathways.

Baricitinib helps treat several diseases, including COVID-19, but has side effects and needs careful monitoring.