In this study, oral testosterone administered three times daily normalized serum testosterone levels in men with experimentally induced hypogonadism over nine days and significantly reduced SHBG.
14 citations
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February 2015 in “Journal of the American Animal Hospital Association” This study reports that transdermal exposure to owners' topical hormone replacement therapy caused alopecia in six dogs, but the condition resolved after the therapy was discontinued.
October 2024 in “Journal of the Endocrine Society” In this case report, a 62-year-old woman with hyperandrogenism and polycythemia was diagnosed with a rare ovarian steroid cell tumor, highlighting the importance of considering such tumors in similar presentations; surgical removal led to symptom and lab normalization.
1 citations
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July 2024 in “Indian Journal of Case Reports” This article presents a case study of a 16-year-old male with GAPO syndrome, characterized by growth retardation, alopecia, pseudoanodontia, and optic atrophy, who sought dental treatment for missing teeth.
September 2021 in “International journal of Ayurveda and pharma research” In this case report, a patient with subclinical hypothyroidism exhibited a significant reduction in TSH levels after four months of ayurvedic treatment, but levels slightly increased afterward.
In this study using mouse models, researchers found that stress-related hair loss may occur due to CRH-induced PTEN loss and inhibition of autophagy via the PI3K/AKT/mTOR pathway in dermal papilla cells, suggesting potential treatments through PTEN activation or autophagy enhancement.
October 2025 in “Journal of the Endocrine Society” In this case study, a 68-year-old woman with hyperandrogenism and presumed ovarian origin responded well to GnRH agonist therapy, normalizing testosterone levels and stabilizing blood pressure, suggesting its effectiveness as a non-surgical treatment option.
37 citations
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November 2002 in “Biology of Reproduction” This study found that prenatal antiandrogen treatment in female spotted hyenas significantly altered the LH response to GnRH, indicating partial masculinization of their anterior pituitary gland without affecting ovulatory function.
34 citations
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July 2006 in “Clinics in dermatology” This article reviews dermatological manifestations of endocrine diseases in dogs, such as hypothyroidism and hyperadrenocorticism, but reports no new clinical findings.
November 2022 in “Journal of the Endocrine Society” In this case study, a woman with high 25(OH)D levels and persistent symptoms showed decreased parathormone after transdermal estrogen therapy, highlighting the importance of assessing both parathormone and estrogen levels in similar patients.
12 citations
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December 2016 in “The FASEB Journal” This study found that the absence of vitamin D receptor-mediated suppression of PPARγ expression causes hair loss in VDR-null mice.
26 citations
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April 2007 in “Journal of pediatric gastroenterology and nutrition” This case report describes an adolescent girl with polycystic ovarian syndrome and endogenously elevated androgen levels who developed a hepatic adenoma, suggesting a link between the two conditions.
25 citations
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September 2014 in “Pharmacotherapy” This review covers cross-sex hormone therapy for gender dysphoria, noting improvements in psychological symptoms and quality of life but lacking definitive long-term safety data.
6 citations
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July 1975 in “Archives of Dermatology” This case report discusses two female patients experiencing significant hair loss, potentially linked to a weight loss regimen involving chorionic gonadotropin injections.
January 2026 in “Brazilian Journal of Development” This case study reported on a 62-year-old woman with ovarian hyperthecosis, which caused symptoms like hirsutism and elevated testosterone; after bilateral oophorectomy, her symptoms improved, suggesting the importance of considering this rare condition in hyperandrogenism diagnosis for postmenopausal women.
73 citations
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January 1997 in “British Journal of Ophthalmology” This study found that three wall orbital decompression by the coronal approach effectively reduces proptosis in Graves' ophthalmopathy patients with fewer complications compared to other techniques.
August 2020 in “Research Square (Research Square)” This study found that PD-MSCs overexpressing PRL-1 inhibited adipogenesis in orbital fibroblasts from Graves' ophthalmopathy patients, potentially offering a new therapeutic approach for degenerative diseases.
2 citations
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January 1986 in “Dermatology” This letter discusses alopecia universalis and Kallman’s Syndrome, and offers no new clinical results.
September 2024 in “Medicine theory and practice” In a clinical case study, researchers identified adrenocortical adenoma as the cause of hyperandrogenism syndrome in a preschool-aged girl, following a comprehensive diagnostic process and successful surgical intervention to remove the tumor, leading to positive clinical improvements.
17 citations
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May 1995 in “Anatomy and Embryology” This study found that treating neonatal mice with the neurotoxin 6-OHDA resulted in temporary hair loss and thinner skin compared to control mice, linking sympathetic neurons to hair growth and skin thickness.
1 citations
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August 2021 in “NeoReviews” This case report describes a successful outcome for a fetus with a neck mass attributed to unnecessary maternal PTU treatment for transient hyperthyroidism, highlighting the importance of accurate diagnosis and careful management.
9 citations
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January 2005 in “Experimental Dermatology” This study found that human hair follicles can function like a peripheral hypothalamic-pituitary-adrenal axis, synthesizing cortisol in response to corticotropin-releasing hormone and adrenocorticotropic hormone stimulation.
April 2020 in “Journal of the Endocrine Society” This case report describes a 22-year-old woman with hirsutism and irregular menstrual bleeding, diagnosed with an ovarian steroid cell tumor (NOS), whose androgen levels normalized after surgery.
6 citations
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June 2004 in “Dermatologic Surgery” This study identified acute localized telogen effluvium as a histopathologic mechanism for temporal hair loss following rhytidectomy.
31 citations
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April 2016 in “Journal of the American Academy of Dermatology” Oral dexamethasone may help regrow hair in adults with alopecia totalis and universalis.
June 2020 in “AACE clinical case reports” This case report illustrates that Leydig cell tumors, despite causing significantly elevated androgen levels, can be difficult to localize due to their small size, as demonstrated in a 42-year-old woman whose tumor was only identified after oophorectomy.
489 citations
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June 2005 in “The FASEB Journal” This study found that human scalp hair follicles can respond to corticotropin releasing hormone stimulation similarly to the classical HPA axis, including up-regulating cortisol production and activating neuroendocrine feedback loops.
November 2022 in “Journal of the Endocrine Society” This case study highlights the complexity of managing PCOS and its symptoms in transmen, suggesting hormonal fluctuations may lead to symptomatic relief with low dose estradiol.
This study suggests that topically applied thyroid hormones T3 and T4 promote hair growth on human scalp tissues ex vivo, highlighting potential therapeutic use for hair loss conditions like androgenetic alopecia.
October 2025 in “Journal of the Endocrine Society” This case report describes a 36-year-old female patient with panhypopituitarism, experiencing severe adrenal insufficiency and thyroid hormone deficiency, which led to electrolyte imbalance, QT interval prolongation, and ventricular tachycardia; treatment stabilized her condition, underscoring the importance of hormonal evaluation in arrhythmia assessment.