Adrenocortical Adenoma as a Cause of Hyperandrogenism Syndrome in a Girl: The Path to Diagnosis
September 2024
in “
Medicine theory and practice
”
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Studysummary In a clinical case study, researchers identified adrenocortical adenoma as the cause of hyperandrogenism syndrome in a preschool-aged girl, following a comprehensive diagnostic process and successful surgical intervention to remove the tumor, leading to positive clinical improvements.
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A 4-year-old girl presented with significant weight gain, acne, pubic hair growth, and clitoral hypertrophy, indicative of hyperandrogenism. Laboratory tests showed elevated levels of testosterone, androstenedione, 17-OH-progesterone, and DHEA-sulfate, along with disrupted cortisol rhythms. Ultrasound and MSCT identified a cystic-solid mass in the left adrenal gland. Surgical removal and histological examination confirmed an adrenocortical adenoma. Postoperative outcomes showed significant clinical and laboratory improvement.
