research Hibiscus Rosa Sinensis Linn: A Review of Its Medicinal Uses and Pharmacological Effects
Hibiscus Rosa Sinensis Linn is a tropical plant used for various medicinal purposes due to its many beneficial properties and components.
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540-570 / 671 results research Loss of TET2 Tips the Scales Toward Tumorigenesis
Loss of TET2 increases the risk of skin and oral cancer.
research Chromatin Remodeler Lymphoid-Specific Helicase (Lsh) Is a Critical Determinant Controlling Postnatal Epidermal Growth, Differentiation, and Response to Injury
Lymphoid-specific helicase (Lsh) is crucial for skin growth, change, and healing after injury.
research Single-Cell RNA Sequencing Reveals POUF51 and HES3 as Regulators of the Stem Cell Population in Psoriasis
POUF51 and HES3 are key in controlling stem cell numbers in psoriasis.
research 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation
TCDD speeds up skin barrier formation by increasing certain gene expressions.
research Physicochemical Properties of pH-Sensitive Hydrogels Based on Hydroxyethyl Cellulose–Hyaluronic Acid for Transdermal Delivery Systems for Skin Lesions
The hydrogel with a 1:3 ratio of hydroxyethyl cellulose to hyaluronic acid is effective for delivering drugs through the skin to treat acne.
research Roles of Tumor Suppressors in Regulating Tumor-Associated Inflammation
Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.
research Regulation of Hair Shedding by the Type 3 IP3 Receptor
The type 3 IP3 receptor is important for controlling hair loss and growth.
research Potential Medical Uses of Cannabigerol: A Brief Overview
CBG may help with various medical conditions but needs more human research to confirm safety and effectiveness.
research Chrysanthemum Zawadskii Extract Induces Hair Growth by Stimulating the Proliferation and Differentiation of Hair Matrix
Chrysanthemum zawadskii extract helps hair grow by stimulating hair cells.
research Chemical Pharmacotherapy Options for Managing Adult Acne
The conclusion is that more research is needed to better understand and treat adult acne, and that patient education and simple treatment plans are important for better results.
research Enhancing Diabetic Wound Healing: Advances in Electrospun Scaffolds from Pathogenesis to Therapeutic Applications
Electrospun scaffolds can improve healing in diabetic wounds.
research Alopecia Areata Susceptibility Variant Identified by MHC Risk Haplotype Sequencing Reproduces Symptomatic Patched Hair Loss in Mice
A gene variant causes patched hair loss in mice, similar to alopecia areata in humans.
research The Effect of Herbal Extract on Hair Growth in Female Androgenetic Alopecia
Herbal extract improves hair growth in female pattern baldness.
research Plasticity of Epithelial Stem Cells in Tissue Regeneration
Epithelial stem cells can adapt and help in tissue repair and regeneration.
research Hair Growth Induction by the Tellurium Immunomodulator AS101: Association with Delayed Terminal Differentiation of Follicular Keratinocytes and Ras-Dependent Up-Regulation of KGF Expression
The substance AS101 can help hair grow by slowing down hair cell aging and boosting a hair growth protein.
research Research Techniques Made Simple: Zebrafish Models for Human Dermatologic Disease
Zebrafish are useful for studying and developing treatments for human skin diseases.
research Integrin Signaling Regulates YAP/TAZ to Control Skin Homeostasis
The study demonstrated that the transcription regulators YAP and TAZ were essential for maintaining skin homeostasis by promoting the proliferation of basal layer stem/progenitor cells. In both mouse and human skin, YAP and TAZ localized in the nucleus of basal layer cells, regulated by integrin-Src signaling. Deletion of YAP and TAZ in mice resulted in slowed cell proliferation, hair loss, and impaired wound healing, underscoring their role in skin regeneration. The research highlighted the importance of integrin-Src and EGFR-PI3K signaling pathways for YAP nuclear localization, which was crucial for cell cycle progression and growth. Additionally, YAP acted as a sensor of epithelial cell polarity, with its localization influenced by apical-basal polarity signals. These findings provided insights into the molecular mechanisms of skin renewal and the potential impact of YAP and TAZ on skin-related conditions and cancer.
research Epidermal Stem Cells in Wound Healing and Their Clinical Applications
Epidermal stem cells help heal severe skin wounds and have potential for medical treatments.
research Folliculin Interacts With P0071 (Plakophilin-4) and Deficiency Is Associated With Disordered RhoA Signalling, Epithelial Polarization, and Cytokinesis
Folliculin deficiency causes problems with cell division and positioning due to disrupted RhoA signaling and interaction with p0071.
research Current Advances of Nanocarrier Technology-Based Active Cosmetic Ingredients for Beauty Applications
Nanocarrier technology in cosmetics improves ingredient delivery and effectiveness while reducing side effects.
research Mutations in the Helix Termination Motif of Mouse Type I IRS Keratin Genes Impair the Assembly of Keratin Intermediate Filament
Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.
research Alopecia Areata Susceptibility Variant in MHC Region Impacts Expressions of Genes Contributing to Hair Keratinization and Is Involved in Hair Loss
A gene variant increases the risk of a type of hair loss by affecting hair protein production.
research Wound Healing With Topical BRAF Inhibitor Therapy in a Diabetic Model Suggests Tissue Regenerative Effects
A topical BRAF inhibitor, vemurafenib, can speed up wound healing and promote hair growth, especially in diabetic patients.
research Connexin 30, A New Marker Of Hyperproliferative Epidermis
Connexin 30 is usually absent in normal skin but can appear in certain skin conditions.
research Enhancing 1α-Hydroxylase Activity with the 25-Hydroxyvitamin D-1α-Hydroxylase Gene in Cultured Human Keratinocytes and Mouse Skin
Adding a specific gene to skin cells can help treat skin disorders like psoriasis.
research Dissecting the Role of the Common Neurotrophin Receptor CD271 in the Skin: Generation and Characterization of a Novel Mouse Model with Keratinocyte-Specific Conditional Deletion
Deleting the CD271 gene in mouse skin cells leads to disorganized skin and increased hair growth, suggesting CD271 is important for skin health.
research Follicles, Fungi, And Scalp Conditions
Malassezia yeast plays a key role in dandruff and seborrhoeic dermatitis.
research Cyclosporine
Cyclosporine, an immunosuppressant targeting CD4+ T lymphocytes, was found to directly affect the growth of various epithelial cell types. It stimulated hair follicle keratinocytes, leading to hypertrichosis, while exerting a cytostatic effect on other epithelial cells. This antiproliferative property was also observed in some cyclosporine analogues with minimal or no immunosuppressive effects, indicating different molecular mechanisms for epithelial cell growth modulation and immunosuppression. This discovery suggested potential for using nonimmunosuppressive cyclosporines in treating hyperproliferative epidermal diseases.
research Circadian Rhythms on Skin Function of Hairless Rats: Light and Thermal Influences
Light and temperature affect the daily skin function rhythms in hairless rats, with temperature influencing water loss but not skin hydration.