June 1995 in “International Journal of Gynecology & Obstetrics” This article compares cabergoline and bromocriptine for treating hyperprolactinemic amenorrhea and reports no specific findings.
78 citations
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November 2008 in “Fertility and Sterility” Amenorrhea is relatively rare and initial testing should check FSH, TSH, and prolactin levels.
38 citations
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October 2006 in “Fertility and Sterility” The document concludes that identifying the cause of amenorrhea is crucial for proper treatment.
30 citations
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July 2004 in “Fertility and Sterility” Amenorrhea is when a woman doesn't have periods, with primary amenorrhea starting by age 15 or within five years of breast development, and secondary amenorrhea when periods stop for three months. It affects 3-4% of women not pregnant, breastfeeding, or in menopause, mainly due to polycystic ovary syndrome, hypothalamic amenorrhea, hyperprolactinemia, and ovarian failure.
21 citations
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September 2004 in “Fertility and Sterility” Amenorrhea, or the absence of periods, should be evaluated by age 15 or within five years of early breast development, and is most commonly caused by conditions like polycystic ovary syndrome and hypothalamic amenorrhea.
3 citations
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January 1988 in “PubMed” This study observed that functional hyperprolactinemia in several women was associated with skin symptoms such as seborrhea, acne, and hair-related issues, resembling androgen-induced conditions.
October 2025 in “Česká gynekologie” This study conducted in fertility clinics in Abbottabad found that hyperprolactinemia is the most prevalent cause of secondary amenorrhea, affecting 31.7% of cases, followed by drug-induced amenorrhea in 14.3% of patients, with oral contraceptives and omeprazole as common factors.
107 citations
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August 2002 in “Journal of Neurology, Neurosurgery, and Psychiatry” Women with epilepsy should be monitored for reproductive issues, which can be caused by epilepsy or its treatments, especially when using valproate.
34 citations
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January 2008 in “International Review of Neurobiology” This review discusses the interplay between epilepsy and reproductive endocrine disorders, examining the factors involved and emphasizing the importance of monitoring but reports no new research findings.
April 2022 in “International Journal of Ayurveda and Pharma Research” This review discusses Ayurvedic perspectives on Polycystic Ovarian Syndrome and highlights correlations with traditional concepts like Nashtarthava, but reports no new clinical findings.
66 citations
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August 1999 in “The Journal of Clinical Endocrinology & Metabolism” This study found that menstrual irregularity is common in women with acromegaly, with high GH levels, estrogen deficiency, and larger tumors correlating with more severe irregularity.
2 citations
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May 2006 in “Women's Health Medicine” This article provides an overview of ovulation disorders, discussing ovarian, hypothalamic, and endocrine defects but reports no new clinical findings.
July 1993 in “学術講演梗概集. A, 材料施工,防火,海洋,情報システム技術” This study observed that hyperprolactinemia in women may be associated with skin and hair symptoms similar to those induced by androgens, suggesting hormone level evaluations in such cases.
June 1995 in “International Journal of Gynecology & Obstetrics” There is no abstract available for this article on the effects of percutaneous oestradiol implants on the skeletons of postmenopausal women, and thus no new findings are reported.
14 citations
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January 1990 in “Fertility and Sterility” In this study, five patients with moderate hyperprolactinemia lacked symptoms, signs, or underlying causes, leading researchers to conclude that no further investigation or therapy was needed.
22 citations
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June 1993 in “Calcified Tissue International” This study found that women with hyperandrogenic amenorrhea do not show reduced bone mineral density compared to controls, indicating they may be protected from osteopenia.
4 citations
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August 2017 in “The Nurse Practitioner” This article discusses the systematic diagnostic evaluation of secondary amenorrhea and provides guidance for referral considerations; it reports no new research findings.
April 2024 in “International Journal of Advanced Multidisciplinary Research and Studies” This study outlines a multidisciplinary approach to investigate primary amenorrhea, emphasizing the necessity to consider medical history, physical examination, and potential hormonal or anatomical causes, and recommends early referral in cases of chromosomal abnormalities or persistent amenorrhea following the development of secondary sexual characteristics.
2 citations
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February 2014 in “Journal of the European Academy of Dermatology and Venereology” This letter reports three cases of diffuse hair loss linked to hyperprolactinaemia but does not present new research findings.
December 2021 in “International Journal of Biomedicine” This review discusses the conflicting perspectives on the relationship between hyperprolactinemia and polycystic ovarian syndrome, emphasizing the need for further evaluation before diagnosing PCOS in the presence of hyperprolactinemia.
January 2024 in “Women's health science journal” This source provides a comprehensive overview of amenorrhea, detailing its classification, potential causes such as hormonal imbalances and structural abnormalities, and the various management strategies including hormone therapy and lifestyle modifications tailored to its underlying causes.
19 citations
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January 2012 in “Dermato-endocrinology” This study suggests that moderate elevated prolactin levels are unlikely to cause significant hair loss in women, but still warrant further diagnostic investigation to rule out a prolactin-producing pituitary tumor.
11 citations
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February 2013 in “Clinical Endocrinology” This study found that the prevalence of hyperprolactinaemia in healthy premenopausal female blood donors is low and not affected by hormonal contraceptive use, with stress-related factors being the most common cause.
November 2023 in “Manuju” This paper discusses the complex relationship between polycystic ovary syndrome (PCOS) and hyperprolactinemia, noting a decrease in prolactin levels following bromocriptine treatment, but reports no new clinical findings.
18 citations
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January 2020 in “Journal of Clinical Research in Pediatric Endocrinology” This review discusses the pathophysiology, diagnosis, and management of functional hypothalamic amenorrhea in adolescent girls and reports no new clinical results.
2 citations
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March 2011 in “Infertility” This review highlights that while lifestyle changes may help with many ovulatory disorders, oocyte donation is considered a viable option for patients who cannot undergo ovulation induction; it reports no new results.
2 citations
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January 2025 in “Medicine” This study in Saudi female patients with hyperprolactinemia found that pituitary imaging is often indicated due to a high prevalence of pituitary anomalies, with prolactin levels showing moderate accuracy in predicting adenomas and a suggested cutoff level of >38.71 ng/mL for diagnosis.
7 citations
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October 2012 in “S. Karger AG eBooks” This review discusses the similarities in clinical, endocrine, and ultrasonographic features between PCOS and other disorders with excessive androgen secretion, emphasizing the importance of accurate diagnosis but reports no new clinical results.
1 citations
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March 2011 in “Infertility” This chapter discusses common endocrine disorders affecting the pituitary, thyroid, and adrenal glands, and their impact on human fertility, emphasizing practical evaluation and treatment algorithms.
1540 citations
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October 2008 in “Fertility and Sterility” This review discusses the definition of polycystic ovary syndrome proposed by the AE-PCOS Society Task Force, emphasizing hyperandrogenism, ovarian dysfunction, and excluding related disorders, while noting potential variations needing more research.