Correlation Between MRI Findings of Pituitary Gland and Prolactin Level Among Hyperprolactinemia Adult Female Saudi Patients in Rural Areas: A Retrospective Multicentric Study

    January 2025 in “ Medicine ”
    Nasher H Alyami, Ghazlan Ali Alhenaki, Salem Al Atwah, Nawras Alhenaki, Fatema Samir Smaisem, Abdullah M. Alotaibi, Joud Abu Risheh, Mustafa Samir Smaisem, Abdulmalik Alhenaki, Sultan Alanazi, Maram Alshammeri, Dana N. Alsayed, Arwa M. Wadaan, Sarah H Musallam, Faisal Ahmed
    Studysummary This study in Saudi female patients with hyperprolactinemia found that pituitary imaging is often indicated due to a high prevalence of pituitary anomalies, with prolactin levels showing moderate accuracy in predicting adenomas and a suggested cutoff level of >38.71 ng/mL for diagnosis. Our plain-language summary of this paper — not a Tressless recommendation.
    This retrospective multicenter study examined 168 Saudi female patients with hyperprolactinemia to explore the correlation between prolactin levels and pituitary adenomas. The study found that elevated prolactin levels were significantly associated with the presence of pituitary adenomas, with 46.1% of patients having microadenomas and 10.2% having macroadenomas. Prolactin levels above 38.71 ng/mL were identified as a moderate predictor of pituitary lesions. The study concluded that prolactin levels are a useful marker for diagnosing pituitary adenomas, emphasizing the need for pituitary imaging in hyperprolactinemic patients. However, it noted limitations such as reliance on secondary data and a limited sample size, suggesting the need for further research with larger samples and extended follow-up.
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